Publications

Publications

Asthma

Royer CM, Rudolph K, Barrett EG. The neonatal susceptibility window for inhalant allergen sensitization in the atopically predisposed canine asthma model. Immunology [Internet]. 2013 Apr [cited 2013 Sep 23];138(4):361–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23181409

Sood A, Qualls C, Seagrave JC, McDonald JD, Shohreh R, Chiavaroli A, et al. Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma. J Asthma [Internet]. 2013 Jun [cited 2014 Feb 20];50(5):449–56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23461590

Vedal S, Campen MJ, McDonald JD, Larson T V, Sampson PD, Sheppard L, et al. National Particle Component Toxicity (NPACT) initiative report on cardiovascular effects. Res Rep Health Eff Inst [Internet]. 2013 Oct [cited 2014 Jan 6];(178):5–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24377210

Mehra D, Sternberg DI, Jia Y, Canfield S, Lemaitre V, Nkyimbeng T, et al. Altered lymphocyte trafficking and diminished airway reactivity in transgenic mice expressing human MMP-9 in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol [Internet]. 2010 Mar [cited 2013 Sep 30];298(2):L189–96. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2822563&tool=pmcentrez&rendertype=abstract

Ye X, Gutierrez B, Zarotsky V, Nelson M, Blanchette CM. Appropriate use of inhaled corticosteroid and long-acting beta(2)-adrenergic agonist combination therapy among asthma patients in a US commercially insured population. Curr Med Res Opin [Internet]. 2009 Sep [cited 2013 Oct 11];25(9):2251–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19622006

Barrett EG. Maternal influence in the transmission of asthma susceptibility. Pulm Pharmacol Ther [Internet]. 2008 Jan [cited 2013 Oct 11];21(3):474–84. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2478516&tool=pmcentrez&rendertype=abstract

Razani-Boroujerdi S, Behl M, Hahn FF, Pena-Philippides JC, Hutt JA, Sopori ML. Role of muscarinic receptors in the regulation of immune and inflammatory responses. J Neuroimmunol [Internet]. 2008 Feb [cited 2013 Oct 14];194(1-2):83–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2323336&tool=pmcentrez&rendertype=abstract

Schwalm K, Stevens JF, Jiang Z, Schuyler MR, Schrader RM, Randell SH, et al. Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects. Am J Physiol Lung Cell Mol Physiol [Internet]. 2008 Jun [cited 2013 Oct 14];294(6):L1102–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18390829

Tesfaigzi Y. Regulation of mucous cell metaplasia in bronchial asthma. Curr Mol Med [Internet]. 2008 Aug [cited 2013 Oct 14];8(5):408–15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18691068

Barrett EG, Henson RD, Seilkop SK, McDonald JD, Reed MD. Effects of hardwood smoke exposure on allergic airway inflammation in mice. Inhal Toxicol [Internet]. 2006 Jan [cited 2013 Oct 18];18(1):33–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16326399

Gao N, Schwartzberg P, Wilder JA, Blazar BR, Yuan D. B cell induction of IL-13 expression in NK cells: role of CD244 and SLAM-associated protein. J Immunol [Internet]. 2006 Mar 1 [cited 2013 Oct 21];176(5):2758–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16493031

Cancer

Filipczak P, Thomas C, Chen W, Salzman A, McDonald J, Lin Y, Belinsky S, “TSC2 deficiency unmasks a novel necrosis pathway that is suppressed by the RIP1/RIP3/MLKL signaling cascade,” Cancer Research 2016.

Leng S, Liu Y, Weissfeld JL, Thomas CL, Han Y, Picchi MA, et al. 15q12 Variants, Sputum Gene Promoter Hypermethylation, and Lung Cancer Risk: A GWAS in Smokers. J Natl Cancer Inst [Internet]. 2015 Jan [cited 2015 Mar 9];107(5). Available from: http://www.ncbi.nlm.nih.gov/pubmed/25713168

Nong Y, Wu D, Lin Y, Zhang Y, Bai L, Tang H. Tenascin-C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF-α-induced TNC expression promotes migration in HCC cells. Am J Cancer Res [Internet]. 2015 Jan [cited 2015 Jun 8];5(2):782–91. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4396033&tool=pmcentrez&rendertype=abstract

Shi S, Wang Q, Xu J, Jang J-H, Padilla MT, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget [Internet]. 2015 Jan 30 [cited 2015 Mar 9];6(3):1640–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25682199

Teneng I, Tellez CS, Picchi MA, Klinge DM, Yingling CM, Snider AM, et al. Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer. Oncogene [Internet]. 2015 Jan 29 [cited 2015 May 4];34(5):621–30. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24469050

He W, Wang Q, Srinivasan B, Xu J, Padilla MT, Li Z, et al. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene [Internet]. 2014 Jun 5 [cited 2014 Jul 10];33(23):3004–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23831571

Nakamura J, Mutlu E, Sharma V, Collins L, Bodnar W, Yu R, et al. The endogenous exposome. DNA Repair (Amst) [Internet]. 2014 Jul [cited 2015 Mar 9];19:3–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24767943

Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, et al. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome. Int J Cancer [Internet]. 2014 Nov 1 [cited 2014 Nov 5];135(9):2223–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24668305

Wrangle J, Machida EO, Danilova L, Hulbert A, Franco N, Zhang W, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin Cancer Res [Internet]. 2014 Apr 1 [cited 2015 Jan 5];20(7):1856–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24486589

Xu X, Wells A, Padilla MT, Kato K, Kim KC, Lin Y. A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis [Internet]. 2014 Aug 1 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25085901

Xu X, Wells A, Padilla MT, Kato K, Kim KC, Lin Y. A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis [Internet]. 2014 Nov [cited 2015 Apr 13];35(11):2457–66. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4216053&tool=pmcentrez&rendertype=abstract

Bruse SE, Petersen H V, Weissfeld J, Picchi MA, Willink RP, Do KC, et al. Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion. Respir Res [Internet]. 2014 Jan [cited 2014 Feb 4];15(1):2. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3893562&tool=pmcentrez&rendertype=abstract

Tessema M, Yingling CM, Snider AM, Do KC, Juri DE, Picchi MA, et al. GATA2 is Epigenetically Repressed in Human and Mouse Lung Tumors and Is Not Requisite for Survival of KRAS Mutant Lung Cancer. J Thorac Oncol [Internet]. 2014 Jun [cited 2014 Jun 2];9(6):784–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24807155

Wang Q, Chen W, Bai L, Chen W, Padilla MT, Lin AS, et al. Receptor-interacting protein 1 increases chemoresistance by maintaining inhibitor of apoptosis protein levels and reducing reactive oxygen species through a microRNA-146a-mediated catalase pathway. J Biol Chem [Internet]. 2014 Feb 28 [cited 2014 May 5];289(9):5654–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24425875

Xu X, Padilla MT, Li B, Wells A, Kato K, Tellez CS, et al. MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res [Internet]. 2014 Jan 15 [cited 2014 Mar 24];74(2):460–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24282280

Xu X, Wells A, Padilla MT, Kato K, Kim KC, Lin Y. A miR-551b/catalase/MUC1/EGFR cascade for acquired apoptosis resistance and chemoresistance in lung cancer cells. AACR Annual Meeting. San Diego, CA; 2014.

Karp DD, Lee SJ, Keller SM, Wright GS, Aisner S, Belinsky SA, et al. Randomized, Double-Blind, Placebo-Controlled, Phase III Chemoprevention Trial of Selenium Supplementation in Patients With Resected Stage I Non-Small-Cell Lung Cancer: ECOG 5597. J Clin Oncol [Internet]. 2013 Sep 3 [cited 2013 Nov 16];31(33):4179–87. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24002495

Leng S, Liu Y, Thomas CL, Gauderman WJ, Picchi MA, Bruse SE, et al. Native american ancestry affects the risk for gene methylation in the lungs of Hispanic smokers from new Mexico. Am J Respir Crit Care Med [Internet]. 2013 Nov 1 [cited 2013 Nov 21];188(9):1110–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24032348

Leng S, Picchi MA, Liu Y, Thomas CL, Willis DG, Bernauer AM, et al. Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau. Carcinogenesis [Internet]. 2013 May [cited 2013 Nov 21];34(5):1044–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23354305

Pawloski PA, Geiger AM, Haque R, Kamineni A, Fouayzi H, Ogarek J, et al. Fracture risk in older, long-term survivors of early-stage breast cancer. J Am Geriatr Soc [Internet]. 2013 Jun [cited 2014 Feb 20];61(6):888–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23647433

Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, et al. Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. Br J Cancer [Internet]. 2013 Oct 1 [cited 2013 Nov 21];109(7):1775–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24045660

Scott BR. First generation stochastic gene episilencing (step1) model and applications to in vitro carcinogen exposure. Dose Response [Internet]. 2013 Jan [cited 2013 Sep 23];11(1):9–28. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3578451&tool=pmcentrez&rendertype=abstract

Bai L, Xu X, Wang Q, Xu S, Ju W, Wang X, et al. A superoxide-mediated mitogen-activated protein kinase phosphatase-1 degradation and c-Jun NH(2)-terminal kinase activation pathway for luteolin-induced lung cancer cytotoxicity. Mol Pharmacol [Internet]. 2012 Apr [cited 2013 Sep 24];81(4):549–55. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3310416&tool=pmcentrez&rendertype=abstract

Bruce V, Belinsky SA, Gott KM, Liu Y, March TH, Scott BR, et al. Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. Dose Response. 2012;10(4):516–26.

Chen W, Xu X, Bai L, Padilla MT, Gott KM, Leng S, et al. Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen. Carcinogenesis [Internet]. 2012 Jul [cited 2014 Feb 19];33(7):1368–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22556270

Leng S, Do KC, Yingling CM, Picchi MA, Wolf HJ, Kennedy TC, et al. Defining a gene promoter methylation signature in sputum for lung cancer risk assessment. Clin Cancer Res [Internet]. 2012 Jun 15 [cited 2013 Sep 24];18(12):3387–95. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3483793&tool=pmcentrez&rendertype=abstract

Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, et al. Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study. Cancer Res [Internet]. 2012 Feb 1 [cited 2013 Sep 24];72(3):707–15. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3271143&tool=pmcentrez&rendertype=abstract

Liu Y, Bernauer AM, Yingling CM, Belinsky SA. HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer. Carcinogenesis [Internet]. 2012 Jun [cited 2013 Sep 24];33(6):1187–92. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3388491&tool=pmcentrez&rendertype=abstract

Tessema M, Yingling CM, Grimes MJ, Thomas CL, Liu Y, Leng S, et al. Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. PLoS One [Internet]. 2012 Jan [cited 2013 Sep 24];7(4):e34850. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3319602&tool=pmcentrez&rendertype=abstract

Tessema M, Yingling CM, Thomas CL, Klinge DM, Bernauer AM, Liu Y, et al. SULF2 methylation is prognostic for lung cancer survival and increases sensitivity to topoisomerase-I inhibitors via induction of ISG15. Oncogene [Internet]. 2012 Sep 13 [cited 2013 Sep 24];31(37):4107–16. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3307938&tool=pmcentrez&rendertype=abstract

Bai L, Xu S, Chen W, Li Z, Wang X, Tang H, et al. Blocking NF-κB and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death. Apoptosis [Internet]. 2011 Jan [cited 2013 Sep 24];16(1):45–54. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3079540&tool=pmcentrez&rendertype=abstract

Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, et al. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res [Internet]. 2011 Jan 15 [cited 2013 Sep 24];71(2):454–62. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3075424&tool=pmcentrez&rendertype=abstract

Chen W, Li Z, Bai L, Lin Y. NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front Biosci (Landmark Ed [Internet]. 2011 Jan [cited 2013 Sep 24];16:1172–85. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3032584&tool=pmcentrez&rendertype=abstract

Leng S, Bernauer AM, Hong C, Do KC, Yingling CM, Flores KG, et al. The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res [Internet]. 2011 Apr 1 [cited 2013 Sep 24];17(7):2014–23. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3070839&tool=pmcentrez&rendertype=abstract

Li Z, Xu X, Bai L, Chen W, Lin Y. Epidermal growth factor receptor-mediated tissue transglutaminase overexpression couples acquired tumor necrosis factor-related apoptosis-inducing ligand resistance and migration through c-FLIP and MMP-9 proteins in lung cancer cells. J Biol Chem [Internet]. 2011 Jun 17 [cited 2013 Sep 24];286(24):21164–72. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3122178&tool=pmcentrez&rendertype=abstract

Scott BR. Residential radon appears to prevent lung cancer. Dose Response [Internet]. 2011 Jan [cited 2013 Sep 24];9(4):444–64. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3315166&tool=pmcentrez&rendertype=abstract

Tellez CS, Juri DE, Do KC, Bernauer AM, Thomas CL, Damiani LA, et al. EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res [Internet]. 2011 Apr 15 [cited 2013 Sep 24];71(8):3087–97. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3078195&tool=pmcentrez&rendertype=abstract

Chen W, Bai L, Wang X, Xu S, Belinsky SA, Lin Y. Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. Mol Pharmacol [Internet]. 2010 Mar [cited 2013 Sep 27];77(3):416–23. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2835422&tool=pmcentrez&rendertype=abstract

Kuehl PJ, Belinsky SA, Chand R, Channell MM, Lucak J, McDonald JD, et al. Pharmacokinetic comparison and analysis of aqueous and dry powder inhalation formulations of 5-azacytidine. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 2. Richmond VA: Virginia Commonwealth University; 2010. p. 627–31.

Lin Y, Bai L, Chen W, Xu S. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets [Internet]. 2010 Jan [cited 2013 Sep 30];14(1):45–55. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3043547&tool=pmcentrez&rendertype=abstract

Stidley CA, Picchi MA, Leng S, Willink RP, Crowell RE, Flores KG, et al. Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers. Cancer Res [Internet]. 2010 Jan 15 [cited 2013 Sep 30];70(2):568–74. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3076796&tool=pmcentrez&rendertype=abstract

Tessema M, Klinge DM, Yingling CM, Do KC, Van Neste L, Belinsky SA. Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene [Internet]. 2010 Sep 16 [cited 2013 Sep 30];29(37):5159–70. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2940978&tool=pmcentrez&rendertype=abstract

Torres SM, March TH, Carter MM, McCash CL, Seilkop SK, Poirier MC, et al. In utero exposure of female CD-1 Mice to AZT and/or 3TC: I. Persistence of microscopic lesions in cardiac tissue. Cardiovasc Toxicol [Internet]. 2010 Mar [cited 2013 Sep 30];10(1):37–50. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2867104&tool=pmcentrez&rendertype=abstract

Bai L, Chen W, Wang X, Ju W, Xu S, Lin Y. Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. J Cell Biochem [Internet]. 2009 Dec 1 [cited 2013 Sep 30];108(5):1125–31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3071149&tool=pmcentrez&rendertype=abstract

Bai L, Chen W, Chen W, Wang X, Tang H, Lin Y. IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells. Mol Cancer Ther [Internet]. 2009 Jun [cited 2013 Sep 30];8(6):1636–45. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2697389&tool=pmcentrez&rendertype=abstract

Bailey VJ, Easwaran H, Zhang Y, Griffiths E, Belinsky SA, Herman JG, et al. MS-qFRET: a quantum dot-based method for analysis of DNA methylation. Genome Res [Internet]. 2009 Aug [cited 2013 Sep 30];19(8):1455–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2720185&tool=pmcentrez&rendertype=abstract

Davies MA, Stemke-Hale K, Lin E, Tellez CS, Deng W, Gopal YN, et al. Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma. Clin Cancer Res [Internet]. 2009 Dec 15 [cited 2013 Sep 30];15(24):7538–46. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2805170&tool=pmcentrez&rendertype=abstract

Li J, Jia H, Xie L, Wang X, He H, Lin Y, et al. Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma. Gynecol Oncol [Internet]. 2009 Jul [cited 2013 Oct 7];114(1):89–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19359031

Lyon CM, Klinge DM, Do KC, Grimes MJ, Thomas CL, Damiani LA, et al. Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model. Carcinogenesis [Internet]. 2009 Dec [cited 2013 Oct 7];30(12):2095–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2792320&tool=pmcentrez&rendertype=abstract

Pulling LC, Grimes MJ, Damiani LA, Juri DE, Do KC, Tellez CS, et al. Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer. Carcinogenesis [Internet]. 2009 Dec [cited 2013 Oct 3];30(12):2023–30. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2792322&tool=pmcentrez&rendertype=abstract

Scott BR, Belinsky SA, Leng S, Lin Y, Wilder JA, Damiani LA. Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer. Dose Response [Internet]. 2009 Jan [cited 2013 Oct 7];7(2):104–31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2695570&tool=pmcentrez&rendertype=abstract

Tessema M, Yu YY, Stidley CA, Machida EO, Schuebel KE, Baylin SB, et al. Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis [Internet]. 2009 Jul [cited 2013 Oct 7];30(7):1132–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2704285&tool=pmcentrez&rendertype=abstract

Walker DM, Kajon AE, Torres SM, Carter MM, McCash CL, Swenberg JA, et al. WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication. Environ Mol Mutagen [Internet]. 2009 Jul [cited 2013 Oct 7];50(6):460–72. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3197270&tool=pmcentrez&rendertype=abstract

Belinsky SA, Schiller JH, Stidley CA. DNA methylation biomarkers to assess therapy and chemoprevention for non-small cell lung cancer. Nutr Rev [Internet]. 2008 Aug [cited 2013 Oct 11];66 Suppl 1:S24–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2683838&tool=pmcentrez&rendertype=abstract

Brock M V, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med [Internet]. 2008 Mar 13 [cited 2013 Oct 11];358(11):1118–28. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18337602

Chen W, Wang X, Bai L, Liang X, Zhuang J, Lin Y. Blockage of NF-kappaB by IKKbeta- or RelA-siRNA rather than the NF-kappaB super-suppressor IkappaBalpha mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells. J Cell Biochem [Internet]. 2008 Oct 1 [cited 2013 Oct 11];105(2):554–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2688738&tool=pmcentrez&rendertype=abstract

Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, et al. A SNP in a let-7 microRNA complementary site in the KRAS 3’ untranslated region increases non-small cell lung cancer risk. Cancer Res [Internet]. 2008 Oct 15 [cited 2013 Oct 8];68(20):8535–40. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2672193&tool=pmcentrez&rendertype=abstract

Damiani LA, Yingling CM, Leng S, Romo PE, Nakamura J, Belinsky SA. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res [Internet]. 2008 Nov 1 [cited 2013 Oct 11];68(21):9005–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18974146

Leng S, Stidley CA, Bernauer AM, Picchi MA, Sheng X, Frasco MA, et al. Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. Carcinogenesis [Internet]. 2008 Jul [cited 2013 Oct 14];29(7):1380–5. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2899849&tool=pmcentrez&rendertype=abstract

Leng S, Stidley CA, Willink RP, Bernauer AM, Do KC, Picchi MA, et al. Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. Cancer Res [Internet]. 2008 Apr 15 [cited 2013 Oct 14];68(8):3049–56. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2483467&tool=pmcentrez&rendertype=abstract

Lin Y, Shi R, Wang X, Shen H-M. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets [Internet]. 2008 Nov [cited 2013 Oct 14];8(7):634–46. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=2615542&tool=pmcentrez&rendertype=abstract

Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res [Internet]. 2008 Feb 15 [cited 2013 Oct 14];68(4):1037–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18281478

Sanders CL, Scott BR. Smoking and hormesis as confounding factors in radiation pulmonary carcinogenesis. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(1):53–79. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2477723&tool=pmcentrez&rendertype=abstract

Scott BR. Low-dose-radiation stimulated natural chemical and biological protection against lung cancer. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(3):299–318. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2564762&tool=pmcentrez&rendertype=abstract

Scott BR, Sanders CL, Mitchel RE, Boreham DR. CT Scans May Reduce Rather Than Increase the Risk of Cancer. J Am Physicians Surg. 2008;13(1):8–11.

Tessema M, Belinsky SA. Mining the epigenome for methylated genes in lung cancer. Proc Am Thorac Soc [Internet]. 2008 Dec 1 [cited 2013 Sep 25];5(8):806–10. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2645235&tool=pmcentrez&rendertype=abstract

Tessema M, Willink RP, Do KC, Yu YY, Yu W, Machida EO, et al. Promoter methylation of genes in and around the candidate lung cancer susceptibility locus 6q23-25. Cancer Res [Internet]. 2008 Mar 15 [cited 2013 Oct 14];68(6):1707–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18339850

Wakamatsu N, Collins JB, Parker JS, Tessema M, Clayton NP, Ton T-VT, et al. Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors. Toxicol Pathol [Internet]. 2008 Jul [cited 2013 Sep 28];36(5):743–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18648096

Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, et al. Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol Cancer Ther [Internet]. 2008 May [cited 2013 Oct 14];7(5):1156–63. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2715176&tool=pmcentrez&rendertype=abstract

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Belinsky SA, Grimes MJ, Casas E, Stidley CA, Franklin WA, Bocklage TJ, et al. Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum. Br J Cancer [Internet]. 2007 Apr 23 [cited 2013 Oct 14];96(8):1278–83. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2360148&tool=pmcentrez&rendertype=abstract

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Chen W, Wang X, Zhuang J, Zhang L, Lin Y. Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells. Carcinogenesis [Internet]. 2007 Oct [cited 2013 Oct 14];28(10):2114–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17548900

Geiger AM, Thwin SS, Lash TL, Buist DSM, Prout MN, Wei F, et al. Recurrences and second primary breast cancers in older women with initial early-stage disease. Cancer [Internet]. 2007 Mar 1 [cited 2013 Oct 14];109(5):966–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17243096

Hahn FF, Gigliotti AP, Hutt JA. Comparative oncology of lung tumors. Toxicol Pathol [Internet]. 2007 Jan [cited 2013 Oct 14];35(1):130–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17325981

Hahn FF, Gigliotti AP, Hutt JA, March TH, Mauderly JL. A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice. Int J Toxicol [Internet]. 2007 [cited 2013 Oct 14];26(4):307–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17661221

Ju W, Wang X, Shi H, Chen W, Belinsky SA, Lin Y. A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol [Internet]. 2007 May [cited 2013 Oct 14];71(5):1381–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17296806

Kagan J, Srivastava S, Barker PE, Belinsky SA, Cairns P. Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI’s EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools. Cancer Res [Internet]. 2007 May 15 [cited 2013 Oct 14];67(10):4545–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17510378

Liu H, Zhou Y, Boggs SE, Belinsky SA, Liu J. Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B. Oncogene [Internet]. 2007 Aug 30 [cited 2013 Oct 14];26(40):5900–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17369845

Meng Q, Olivero OA, Fasco MJ, Bellisario R, Kaminsky L, Pass KA, et al. Plasma and cellular markers of 3’-azido-3'-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs. Environ Mol Mutagen [Internet]. 2007 [cited 2013 Oct 14];48(3-4):307–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17358024

Razani-Boroujerdi S, Sopori ML. Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. Am J Respir Cell Mol Biol [Internet]. 2007 Jan [cited 2013 Oct 14];36(1):13–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1899301&tool=pmcentrez&rendertype=abstract

Torres SM, Walker DM, Carter MM, Cook DL, McCash CL, Cordova EM, et al. Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations. Environ Mol Mutagen [Internet]. 2007 [cited 2013 Oct 16];48(3-4):224–38. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17358033

Walker DM, Malarkey DE, Seilkop SK, Ruecker FA, Funk KA, Wolfe MJ, et al. Transplacental carcinogenicity of 3’-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats. Environ Mol Mutagen [Internet]. 2007 [cited 2013 Oct 16];48(3-4):283–98. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17358026

Wang X, Chen W, Lin Y. Sensitization of TNF-induced cytotoxicity in lung cancer cells by concurrent suppression of the NF-kappaB and Akt pathways. Biochem Biophys Res Commun [Internet]. 2007 Apr 13 [cited 2013 Oct 16];355(3):807–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17316570

Belinsky SA, Liechty KC, Gentry FD, Wolf HJ, Rogers J, Vu K, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res [Internet]. 2006 Mar 15 [cited 2013 Oct 21];66(6):3338–44. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16540689

Divine KK, Liechty KC, Crume KC, Belinsky SA. Nested multigene MSP/DHPLC method for analyzing promoter hypermethylation status in clinical samples. Biotechniques [Internet]. 2006 Jan [cited 2013 Oct 21];40(1):40, 42, 44 passim. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16454038

Enger SM, Thwin SS, Buist DSM, Field TS, Frost FJ, Geiger AM, et al. Breast cancer treatment of older women in integrated health care settings. J Clin Oncol [Internet]. 2006 Sep 20 [cited 2013 Oct 21];24(27):4377–83. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1913483&tool=pmcentrez&rendertype=abstract

Machida EO, Brock M V, Hooker CM, Nakayama J, Ishida A, Amano J, et al. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Res [Internet]. 2006 Jun 15 [cited 2013 Oct 21];66(12):6210–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16778195

Scott BR. Re: Risk of thyroid cancer after exposure to (131)I in childhood. J Natl Cancer Inst [Internet]. 2006 Apr 19 [cited 2013 Oct 24];98(8):561; author reply 561. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16622126

Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Cogliano V. Carcinogenicity of household solid fuel combustion and of high-temperature frying. Lancet Oncol [Internet]. 2006 Dec [cited 2014 Feb 25];7(12):977–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17348122

Vuillemenot BR, Hutt JA, Belinsky SA. Gene promoter hypermethylation in mouse lung tumors. Mol Cancer Res [Internet]. 2006 Apr [cited 2013 Oct 24];4(4):267–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16603640

Wang X, Ju W, Renouard J, Aden JK, Belinsky SA, Lin Y. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer Res [Internet]. 2006 Jan 15 [cited  2013 Oct 24];66(2):1089–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16424045

Belinsky SA. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis [Internet]. 2005 Sep [cited 2013 Oct 25];26(9):1481–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15661809

Belinsky SA, Klinge DM, Dekker JD, Smith MW, Bocklage TJ, Gilliland FD, et al. Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clin Cancer Res [Internet]. 2005 Sep 15 [cited 2013 Oct 25];11(18):6505–11. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16166426

COPD

Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, et al. Protective role for club cell secretory protein-16 (CC16) in the development of chronic obstructive pulmonary disease. Eur Respir J [Internet]. 2015 Feb 19 [cited 2015 Mar 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25700379

Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, et al. B-cell Activating Factor: An Orchestrator of Lymphoid Follicles in Severe COPD. Am J Respir Crit Care Med [Internet]. 2015 Jun 13 [cited 2015 Jul 10]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26073875

Chand HS, Montano G, Huang X, Randell SH, Mebratu YA, Petersen H V, et al. A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression. Nat Commun [Internet]. 2014 Jan [cited 2014 Dec 8];5:5567. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25429397

Cheng Y, Borrego ME, Frost FJ, Petersen H V, Raisch DW. Predictors for mortality in hospitalized patients with chronic obstructive pulmonary disease. Springerplus [Internet]. 2014 Jan [cited 2014 Aug 6];3:359. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4108717&tool=pmcentrez&rendertype=abstract

Delgado M, Tesfaigzi Y. Is BMF central for anoikis and autophagy? Autophagy [Internet]. 2014 Jan [cited 2014 Sep 9];10(1):168–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24225781

Moon H-G, Kim S-H, Gao J, Quan T, Qin Z, Osorio JC, et al. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol [Internet]. 2014 Aug 15 [cited 2014 Oct 23];307(4):L326–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24973403

Contreras AU, Mebratu YA, Delgado M, Montano G, Hu C-AA, Ryter SW, et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol [Internet]. 2013 Apr 29 [cited 2013 Sep 23];201(3):427–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23629966

Delgado M, Tesfaigzi Y. BH3-only proteins, Bmf and Bim, in autophagy. Cell Cycle [Internet]. 2013 Nov 15 [cited 2013 Nov 21];12(22):3453–4. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3906325&tool=pmcentrez&rendertype=abstract

Gundavarapu S, Mishra NC, Singh SP, Langley RJ, Saeed AI, Feghali-Bostwick CA, et al. HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. PLoS One [Internet]. 2013 Jan [cited 2013 Nov 21];8(10):e77160. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3796539&tool=pmcentrez&rendertype=abstract

Mapel DW, Roberts MH, Blanchette CM, Petersen H V, Ramachandran S. Effectiveness of inhaled combined corticosteroid/long acting bronchodilator treatment in reducing COPD exacerbations and short-acting bronchodilator use. J Clin Outcomes Manag. 2013;20(2):60–8 – 68.

Petersen H V, Sood A, Meek P, Shen X, Cheng Y, Belinsky SA, et al. Rapid Lung Function Decline in Smokers is a Risk Factor for COPD and is Attenuated by ACE Inhibitor Use. Chest [Internet]. 2013 Sep 5 [cited 2014 Feb 27]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24008986

Roberts MH, Mapel DW, Bruse SE, Petersen H V, Nyunoya T. Development of a modified BODE index as a mortality risk measure among older adults with and without chronic obstructive pulmonary disease. Am J Epidemiol [Internet]. 2013 Oct 1 [cited 2014 Feb 20];178(7):1150–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23928262

Chand HS, Harris JF, Mebratu YA, Chen Y, Wright PS, Randell SH, et al. Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells. J Immunol [Internet]. 2012 May 1 [cited 2013 Sep 17];188(9):4581–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3359962&tool=pmcentrez&rendertype=abstract

Gundavarapu S, Wilder JA, Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, et al. Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. J Allergy Clin Immunol [Internet]. 2012 Sep [cited 2013 Sep 24];130(3):770–80.e11. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3419772&tool=pmcentrez&rendertype=abstract

Roberts MH, Dalal AA. Clinical and economic outcomes in an observational study of COPD maintenance therapies: multivariable regression versus propensity score matching. Int J Chron Obstruct Pulmon Dis [Internet]. 2012 Jan [cited 2013 Sep 24];7:221–33. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3324998&tool=pmcentrez&rendertype=abstract

Seagrave JC, Albrecht HH, Hill DB, Rogers DF, Solomon G. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir Res [Internet]. 2012 Jan [cited 2013 Sep 17];13:98. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3545908&tool=pmcentrez&rendertype=abstract

Xu X, Bai L, Chen W, Padilla MT, Liu Y, Kim KC, et al. MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation. PLoS One [Internet]. 2012 Jan [cited 2013 Sep 24];7(3):e33846. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3310874&tool=pmcentrez&rendertype=abstract

Zhang Z, Zhang C, Zhou M, Xu F. Activation of opioid μ-receptors, but not δ- or κ-receptors, switches pulmonary C-fiber-mediated rapid shallow breathing into an apnea in anesthetized rats. Respir Physiol Neurobiol [Internet]. 2012 Sep 30 [cited 2013 Sep 24];183(3):211–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22796630

Zhang Z, Zhang C, Zhuang J, Xu F. Contribution of central μ-receptors to switching pulmonary C-fibers-mediated rapid shallow breathing into an apnea by fentanyl in anesthetized rats. Brain Res [Internet]. 2012 Aug 21 [cited 2013 Sep 24];1469:73–81. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3411907&tool=pmcentrez&rendertype=abstract

Zhuang J, Zhang Z, Zhang C, Xu F. 8-OH-DPAT abolishes the pulmonary C-fiber-mediated apneic response to fentanyl largely via acting on 5HT1A receptors in the nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol [Internet]. 2012 Aug 15 [cited 2013 Sep 24];303(4):R449–58. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3423994&tool=pmcentrez&rendertype=abstract

Abraham G, Zizzadoro C, Kacza J, Ellenberger C, Abs V, Franke J, et al. Growth and differentiation of primary and passaged equine bronchial epithelial cells under conventional and air-liquid-interface culture conditions. BMC Vet Res [Internet]. 2011 Jan [cited 2013 Sep 24];7:26. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3117700&tool=pmcentrez&rendertype=abstract

Blanchette CM, Berry SR, Lane SJ. Advances in chronic obstructive pulmonary disease among older adults. Curr Opin Pulm Med [Internet]. 2011 Mar [cited 2013 Sep 24];17(2):84–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21178625

Blanchette CM, Roberts MH, Petersen H V, Dalal AA, Mapel DW. Economic burden of chronic bronchitis in the United States: a retrospective case-control study. Int J Chron Obstruct Pulmon Dis [Internet]. 2011 Jan [cited 2013 Sep 24];6:73–81. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3034282&tool=pmcentrez&rendertype=abstract

Brehm JM, Hagiwara K, Tesfaigzi Y, Bruse SE, Mariani TJ, Bhattacharya S, et al. Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Thorax [Internet]. 2011 Dec [cited 2013 Sep 24];66(12):1085–90. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3348619&tool=pmcentrez&rendertype=abstract

Bruse SE, Sood A, Petersen H V, Liu Y, Leng S, Celedón JC, et al. New Mexican Hispanic smokers have lower odds of chronic obstructive pulmonary disease and less decline in lung function than non-Hispanic whites. Am J Respir Crit Care Med [Internet]. 2011 Dec 1 [cited 2013 Sep 24];184(11):1254–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3262041&tool=pmcentrez&rendertype=abstract

Choi S, Park YS, Koga T, Treloar A, Kim KC. TNF-α is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection. Am J Respir Cell Mol Biol [Internet]. 2011 Feb [cited 2013 Sep 24];44(2):255–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3049236&tool=pmcentrez&rendertype=abstract

Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, et al. A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell [Internet]. 2011 Jun 10 [cited 2013 Sep 24];42(5):597–609. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3138416&tool=pmcentrez&rendertype=abstract

Dalal AA, Roberts MH, Petersen H V, Blanchette CM, Mapel DW. Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis [Internet]. 2011 Jan [cited 2013 Sep 24];6:13–22. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3034283&tool=pmcentrez&rendertype=abstract

Glasser SW, Senft AP. Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis. Curr Pharm Biotechnol [Internet]. 2011 Sep [cited 2013 Sep 24];12(9):1447–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21401520

Kim J-Y, Morgan M, Kim D-G, Lee J-Y, Bai L, Lin Y, et al. TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci [Internet]. 2011 Feb 15 [cited 2013 Sep 23];124(Pt 4):647–56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21266470

Mapel DW, Dalal AA, Blanchette CM, Petersen H V, Ferguson GT. Severity of COPD at initial spirometry-confirmed diagnosis: data from medical charts and administrative claims. Int J Chron Obstruct Pulmon Dis [Internet]. 2011 Jan [cited 2014 Feb 20];6:573–81. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3224652&tool=pmcentrez&rendertype=abstract

Mebratu YA, Schwalm K, Smith KR, Schuyler MR, Tesfaigzi Y. Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia. Am J Respir Crit Care Med [Internet]. 2011 Jun 1 [cited 2013 Sep 24];183(11):1531–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3137142&tool=pmcentrez&rendertype=abstract

Nyunoya T, March TH, Tesfaigzi Y, Seagrave JC. Antioxidant diet protects against emphysema, but increases mortality in cigarette smoke-exposed mice. COPD [Internet]. 2011 Oct [cited 2013 Sep 24];8(5):362–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3323122&tool=pmcentrez&rendertype=abstract

Roberts MH, Mapel DW, Petersen H V, Blanchette CM, Ramachandran S. Comparative effectiveness of budesonide/formoterol and fluticasone/salmeterol for COPD management. J Med Econ [Internet]. 2011 Jan [cited 2014 Jan 29];14(6):769–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21942463

Seagrave JC, Albrecht HH, Park YS, Rubin B, Solomon G, Kim KC. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res [Internet]. 2011 Dec [cited 2013 Sep 24];37(10):606–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22044398

Silverman EK, Vestbo J, Agusti A, Anderson WH, Bakke PS, Barnes KC, et al. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD [Internet]. 2011 Apr [cited 2013 Sep 24];8(2):121–35. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3082172&tool=pmcentrez&rendertype=abstract

Smith KR, Leonard D, McDonald JD, Tesfaigzi Y. Inflammation, mucous cell metaplasia, and Bcl-2 expression in response to inhaled lipopolysaccharide aerosol and effect of rolipram. Toxicol Appl Pharmacol [Internet]. 2011 Jun 15 [cited 2013 Sep 24];253(3):253–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3103593&tool=pmcentrez&rendertype=abstract

Xu J, Xu F, Lin Y. Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α secretion from macrophages via substance P-mediated nuclear factor-κB activation. Am J Respir Cell Mol Biol [Internet]. 2011 Mar [cited 2013 Sep 27];44(3):302–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3095931&tool=pmcentrez&rendertype=abstract

Zhang Z, Zhuang J, Zhang C, Xu F. Activation of opioid μ-receptors in the commissural subdivision of the nucleus tractus solitarius abolishes the ventilatory response to hypoxia in anesthetized rats. Anesthesiology [Internet]. 2011 Aug [cited 2013 Sep 27];115(2):353–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21716092

Zhuang J, Xu J, Zhang C, Xu F. IL-1β acutely increases pulmonary SP and permeability without associated changes in airway resistance and ventilation in anesthetized rats. Respir Physiol Neurobiol [Internet]. 2011 Jan 31 [cited 2013 Sep 27];175(1):12–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20692381

Charles MS, Blanchette CM, Silver HS, Lavallee D, Dalal AA, Mapel DW. Adherence to controller therapy for chronic obstructive pulmonary disease: a review. Curr Med Res Opin [Internet]. 2010 Oct [cited 2013 Sep 27];26(10):2421–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20815661

Dalal AA, St Charles M, Petersen H V, Roberts MH, Blanchette CM, Manavi-Zieverink K. Cost-effectiveness of combination fluticasone propionate-salmeterol 250/50 microg versus salmeterol in severe COPD patients. Int J Chron Obstruct Pulmon Dis [Internet]. 2010 Jan [cited 2013 Sep 27];5:179–87. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2921685&tool=pmcentrez&rendertype=abstract

Hicks A, Goodnow R, Cavallo G, Tannu SA, Ventre JD, Lavelle D, et al. Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins Other Lipid Mediat [Internet]. 2010 Jun [cited 2013 Sep 27];92(1-4):33–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20214997

Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell [Internet]. 2010 Mar 1 [cited 2013 Sep 30];21(3):481–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2814792&tool=pmcentrez&rendertype=abstract

Mapel DW, Hurley JS, Dalal AA, Blanchette CM. The role of combination inhaled corticosteroid/long-acting beta-agonist therapy in COPD management. Prim Care Respir J [Internet]. 2010 Jun [cited 2013 Sep 30];19(2):93–103. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20339822

Mapel DW, Petersen H V, Roberts MH, Hurley JS, Frost FJ, Marton JP. Can outpatient pharmacy data identify persons with undiagnosed COPD? Am J Manag Care [Internet]. 2010 Jul [cited 2013 Sep 30];16(7):505–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20645666

Pickett G, Seagrave JC, Boggs SE, Polzin G, Richter P, Tesfaigzi Y. Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci [Internet]. 2010 Mar [cited 2013 Sep 30];114(1):79–89. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20015843

Silver HS, Blanchette CM, Kamble S, Petersen H V, Letter MA, Meddis D, et al. Quarterly assessment of short-acting beta(2)-adrenergic agonist use as a predictor of subsequent health care use for asthmatic patients in the United States. J Asthma [Internet]. 2010 Aug [cited 2013 Sep 30];47(6):660–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20615167

Sood A, Petersen H V, Blanchette CM, Meek P, Picchi MA, Belinsky SA, et al. Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers. Am J Respir Crit Care Med [Internet]. 2010 Nov 1 [cited 2013 Sep 30];182(9):1098–104. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3001253&tool=pmcentrez&rendertype=abstract

Blanchette CM, Broder M, Ory C, Chang E, Akazawa M, Dalal AA. Cost and utilization of COPD and asthma among insured adults in the US. Curr Med Res Opin [Internet]. 2009 Jun [cited 2013 Sep 30];25(6):1385–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19419342

Blanchette CM, Culler SD, Ershoff D, Gutierrez B. Association between previous health care use and initiation of inhaled corticosteroid and long-acting beta2-adrenergic agonist combination therapy among US patients with asthma. Clin Ther [Internet]. 2009 Nov [cited 2013 Sep 30];31(11):2574–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20110003

Blanchette CM, Mapel DW, Petersen H V, Drelick A, Charles MS, Ramachandran S. RELATIONSHIP BETWEEN EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND DURATION OF CONTROLLER THERAPY AMONG A COMMERCIALLY INSURED POPULATION IN THE UNITED STATES. Value Health. 2009;12(3):A121.

Blanchette CM, Simoni-Wastila L, Shaya FT, Orwig D, Noel J, Stuart B. Health care use in depressed, elderly, cardiac patients and the effect of antidepressant use. Am J Health Syst Pharm [Internet]. 2009 Mar 15 [cited 2013 Sep 30];66(4):366–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19202046

Blanchette CM, Simoni-Wastila L, Shaya FT, Orwig D, Noel J, Stuart B. Depression following thrombotic cardiovascular events in elderly medicare beneficiaries: risk of morbidity and mortality. Cardiol Res Pract [Internet]. 2009 Jan [cited 2013 Sep 30];2009:194528. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2800999&tool=pmcentrez&rendertype=abstract

Dalal AA, Petersen H V, Simoni-Wastila L, Blanchette CM. Healthcare costs associated with initial maintenance therapy with fluticasone propionate 250 μg/salmeterol 50 μg combination versus anticholinergic bronchodilators in elderly US Medicare-eligible beneficiaries with COPD. J Med Econ [Internet]. 2009 Jan [cited 2013 Sep 30];12(4):339–47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19827993

Delea TE, Hagiwara M, Dalal AA, Stanford RH, Blanchette CM. Healthcare use and costs in patients with chronic bronchitis initiating maintenance therapy with fluticasone/salmeterol vs other inhaled maintenance therapies. Curr Med Res Opin [Internet]. 2009 Jan [cited 2013 Sep 30];25(1):1–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19210134

Guang W, Kim KC, Lillehoj EP. MUC1 mucin interacts with calcium-modulating cyclophilin ligand. Int J Biochem Cell Biol [Internet]. 2009 Jun [cited 2013 Oct 1];41(6):1354–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3718471&tool=pmcentrez&rendertype=abstract

Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med [Internet]. 2009 Dec 31 [cited 2013 Oct 1];361(27):2599–608. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2904064&tool=pmcentrez&rendertype=abstract

Mebratu YA, Tesfaigzi Y. How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle [Internet]. 2009 Apr 15 [cited 2013 Oct 7];8(8):1168–75. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2728430&tool=pmcentrez&rendertype=abstract

Simoni-Wastila L, Blanchette CM, Qian J, Yang H-WK, Zhao L, Zuckerman IH, et al. Burden of chronic obstructive pulmonary disease in Medicare beneficiaries residing in long-term care facilities. Am J Geriatr Pharmacother [Internet]. 2009 Oct [cited 2013 Oct 7];7(5):262–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19948302

Simoni-Wastila L, Yang HK, Blanchette CM, Zhao L, Qian J, Dalal AA. Hospital and emergency department utilization associated with treatment for chronic obstructive pulmonary disease in a managed-care Medicare population. Curr Med Res Opin [Internet]. 2009 Nov [cited 2013 Oct 7];25(11):2729–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19778165

Takeda K, Okamoto M, de Langhe S, Dill E, Armstrong M, Reisdorf N, et al. Peroxisome proliferator-activated receptor-g agonist treatment increases septation and angiogenesis and decreases airway hyperresponsiveness in a model of experimental neonatal chronic lung disease. Anat Rec (Hoboken) [Internet]. 2009 Jul [cited 2013 Oct 7];292(7):1045–61. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2873208&tool=pmcentrez&rendertype=abstract

Wheeler DS, Chase MA, Senft AP, Poynter SE, Wong HR, Page K. Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4. Respir Res [Internet]. 2009 Jan [cited 2013 Oct 11];10:31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2679007&tool=pmcentrez&rendertype=abstract

Zhang Z, Xu F, Zhang C, Liang X. Opioid mu-receptors in medullary raphe region affect the hypoxic ventilation in anesthetized rats. Respir Physiol Neurobiol [Internet]. 2009 Sep 30 [cited 2013 Oct 11];168(3):281–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3438222&tool=pmcentrez&rendertype=abstract

Zhang Z, Xu F, Zhang C, Liang X. Activation of opioid micro-receptors in medullary raphe depresses sighs. Am J Physiol Regul Integr Comp Physiol [Internet]. 2009 May [cited 2013 Oct 11];296(5):R1528–37. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2689826&tool=pmcentrez&rendertype=abstract

Zhuang J, Xu F, Zhang C, Frazier DT. Passive limb movement augments ventilatory response to CO2 via sciatic inputs in anesthetized rats. Respir Physiol Neurobiol [Internet]. 2009 Jun 30 [cited 2013 Oct 11];167(2):174–80. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3466119&tool=pmcentrez&rendertype=abstract

Blanchette CM, Akazawa M, Dalal AA, Simoni-Wastila L. Risk of hospitalizations/emergency department visits and treatment costs associated with initial maintenance therapy using fluticasone propionate 500 microg/salmeterol 50 microg compared with ipratropium for chronic obstructive pulmonary disease in older. Am J Geriatr Pharmacother [Internet]. 2008 Aug [cited 2013 Oct 11];6(3):138–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18775388

Blanchette CM, Gutierrez B, Ory C, Chang E, Akazawa M. Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population. J Manag Care Pharm [Internet]. 2008 Mar [cited 2013 Oct 11];14(2):176–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18331119

Blanchette CM, Simoni-Wastila L, Zuckerman IH, Stuart B. A secondary analysis of a duration response association between selective serotonin reuptake inhibitor use and the risk of acute myocardial infarction in the aging population. Ann Epidemiol [Internet]. 2008 Apr [cited 2013 Oct 11];18(4):316–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18261924

Kim KC, Lillehoj EP. MUC1 mucin: a peacemaker in the lung. Am J Respir Cell Mol Biol [Internet]. 2008 Dec [cited 2013 Oct 11];39(6):644–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2586042&tool=pmcentrez&rendertype=abstract

Lammey ML, Doane CJ, Gigliotti AP, Lee DR, Sleeper MM. Diagnosis and treatment of pulmonary arterial hypertension and atrial fibrillation in an adult chimpanzee (Pan troglodytes). J Am Assoc Lab Anim Sci [Internet]. 2008 Sep [cited 2013 Oct 14];47(5):56–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2691534&tool=pmcentrez&rendertype=abstract

Mebratu YA, Dickey BF, Evans CM, Tesfaigzi Y. The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. J Cell Biol [Internet]. 2008 Nov 3 [cited 2013 Oct 14];183(3):429–39. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2575785&tool=pmcentrez&rendertype=abstract

Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, Pena-Philippides JC, Koga T, et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. J Immunol [Internet]. 2008 Jun 1 [cited 2013 Oct 14];180(11):7655–63. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2614131&tool=pmcentrez&rendertype=abstract

Sood A, Stidley CA, Picchi MA, Celedón JC, Gilliland FD, Crowell RE, et al. Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers. COPD [Internet]. 2008 Oct [cited 2013 Oct 14];5(5):274–81. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3616889&tool=pmcentrez&rendertype=abstract

Ueno K, Koga T, Kato K, Golenbock DT, Gendler SJ, Kai H, et al. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am J Respir Cell Mol Biol [Internet]. 2008 Mar [cited 2013 Oct 14];38(3):263–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2258447&tool=pmcentrez&rendertype=abstract

Xiang J, Rir-sima-ah J, Tesfaigzi Y. IL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway. Am J Respir Cell Mol Biol [Internet]. 2008 Mar [cited 2013 Oct 14];38(3):310–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2258450&tool=pmcentrez&rendertype=abstract

Bredow S, Juri DE, Cardon K, Tesfaigzi Y. Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region. Gene [Internet]. 2007 Dec 1 [cited 2013 Oct 14];404(1-2):110–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2288782&tool=pmcentrez&rendertype=abstract

Frost FJ, Petersen H V, Tollestrup K, Skipper BJ. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest [Internet]. 2007 Apr [cited 2013 Sep 20];131(4):1006–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17426203

Harris JF, Aden J, Lyons CR, Tesfaigzi Y. Resolution of LPS-induced airway inflammation and goblet cell hyperplasia is independent of IL-18. Respir Res [Internet]. 2007 Jan [cited 2013 Oct 14];8:24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1828726&tool=pmcentrez&rendertype=abstract

Kato K, Lu W, Kai H, Kim KC. Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling. Am J Physiol Lung Cell Mol Physiol [Internet]. 2007 Sep [cited 2013 Oct 14];293(3):L686–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17586693

Kuwahara I, Lillehoj EP, Koga T, Isohama Y, Miyata T, Kim KC. The signaling pathway involved in neutrophil elastase stimulated MUC1 transcription. Am J Respir Cell Mol Biol [Internet]. 2007 Dec [cited 2013 Oct 2];37(6):691–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2219551&tool=pmcentrez&rendertype=abstract

Lillehoj EP, Lu W, Kiser T, Goldblum SE, Kim KC. MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism. Biochim Biophys Acta [Internet]. 2007 Jul [cited 2013 Oct 14];1773(7):1028–38. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2349984&tool=pmcentrez&rendertype=abstract

Martinez MJ, Smith AD, Li B, Zhang MQ, Harrod KS. Computational prediction of novel components of lung transcriptional networks. Bioinformatics [Internet]. 2007 Jan 1 [cited 2013 Oct 4];23(1):21–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17050569

Stout BA, Melendez K, Seagrave JC, Holtzman MJ, Wilson BS, Xiang J, et al. STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma. J Immunol [Internet]. 2007 Jun 15 [cited 2013 Oct 16];178(12):8107–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17548649

Zhang Z, Xu F, Zhang C, Liang X. Activation of opioid mu receptors in caudal medullary raphe region inhibits the ventilatory response to hypercapnia in anesthetized rats. Anesthesiology [Internet]. 2007 Aug [cited 2013 Oct 18];107(2):288–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17667574

Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, et al. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol [Internet]. 2006 May [cited 2013 Oct 18];34(5):523–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16618787

Bartner LR, Robinson NE, Kiupel M, Tesfaigzi Y. Persistent mucus accumulation: a consequence of delayed bronchial mucous cell apoptosis in RAO-affected horses? Am J Physiol Lung Cell Mol Physiol [Internet]. 2006 Oct [cited 2013 Oct 18];291(4):L602–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16500947

Mapel DW, Frost FJ, Hurley JS, Petersen H V, Roberts MH, Marton JP, et al. An algorithm for the identification of undiagnosed COPD cases using administrative claims data. J Manag Care Pharm [Internet]. 2006 [cited 2014 Feb 20];12(6):457–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16925453

Pierce J, Rir-Sima-Ah J, Estrada I, Wilder JA, Strasser A, Tesfaigzi Y. Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia. Am J Physiol Lung Cell Mol Physiol [Internet]. 2006 Nov [cited 2013 Oct 24];291(5):L862–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16782750

Tesfaigzi Y. Roles of apoptosis in airway epithelia. Am J Respir Cell Mol Biol [Internet]. 2006 May [cited 2013 Oct 24];34(5):537–47. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2644219&tool=pmcentrez&rendertype=abstract

Tesfaigzi Y, Meek P, Lareau S. Exacerbations of chronic obstructive pulmonary disease and chronic mucus hypersecretion. Clin Appl Immunol Rev. 2006;6(1):21–36.

Tesfaigzi Y, Myers OB, Stidley CA, Schwalm K, Picchi MA, Crowell RE, et al. Genotypes in matrix metalloproteinase 9 are a risk factor for COPD. Int J Chron Obstruct Pulmon Dis [Internet]. 2006 Jan [cited 2013 Oct 24];1(3):267–78. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2707156&tool=pmcentrez&rendertype=abstract

Daheshia M. Pathogenesis of chronic obstructive pulmonary disease (COPD). Clin Appl Immunol Rev. 2005;5(5):339–51.

Daheshia M. Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD). Curr Med Res Opin [Internet]. 2005 Apr [cited 2013 Oct 18];21(4):587–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15899108

Daheshia M, Tesfaigzi Y. The role of matrix metalloproteinases in chronic pulmonary disease: Relevance of the airway eptihelium. Curr Respir Med Rev. 2005;1(2):165–70.

 

Drug Development

Kuehl PJ, Boyden T, Dobry DE, Doyle-Eisele M, Friesen DT, McDonald JD, et al. Inhaled PYY(3-36) dry-powder formulation for appetite suppression. Drug Dev Ind Pharm [Internet]. 2015 May 26 [cited 2015 Jun 8];1–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26006332

Leach CL, Kuehl PJ, Chand R, McDonald JD. Nasal Deposition of HFA-Beclomethasone, Aqueous Fluticasone Propionate and Aqueous Mometasone Furoate in Allergic Rhinitis Patients. J Aerosol Med Pulm Drug Deliv [Internet]. 2015 Feb 11 [cited 2015 Mar 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25671692

Leach CL, Kuehl PJ, Chand R, McDonald JD. Respiratory Tract Deposition of HFA-Beclomethasone and HFA-Fluticasone in Asthmatic Patients. J Aerosol Med Pulm Drug Deliv [Internet]. 2015 Jun 10 [cited 2015 Jul 10]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26061801

Shi S, Wang Q, Xu J, Jang J-H, Padilla MT, Nyunoya T, et al. Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Oncotarget [Internet]. 2015 Jan 30 [cited 2015 Mar 9];6(3):1640–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25682199

T Filipczak P, P Senft A, Seagrave J, Weber W, J Kuehl P, E Fredenburgh L, et al. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury. Toxicol Sci [Internet]. 2015 Apr 13 [cited 2015 May 4]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25870319

Cheng YS, Zhou Y, Su W-C. Deposition of Particles in Human Mouth-Throat Replicas and a USP Induction Port. J Aerosol Med Pulm Drug Deliv [Internet]. 2014 Aug 19 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25137223

Forbes B, O’Lone R, Allen PP, Cahn A, Clarke C, Collinge M, et al. Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses. Adv Drug Deliv Rev [Internet]. 2014 May [cited 2015 Feb 5];71:15–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24530633

Kuehl PJ, Cherrington A, Dobry DE, Edgerton D, Friesen DT, Hobbs CH, et al. Biologic Comparison of Inhaled Insulin Formulations: Exubera(TM) and Novel Spray-Dried Engineered Particles of Dextran-10. AAPS PharmSciTech [Internet]. 2014 Aug 9 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25106135

Salmon M, Tannheimer SL, Gentzler TT, Cui Z-H, Sorensen EA, Hartsough KC, et al. The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species. Pharmacol Res Perspect [Internet]. 2014 Aug [cited 2015 Jan 5];2(4):e00046. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4186437&tool=pmcentrez&rendertype=abstract

Tellez CS, Grimes MJ, Picchi MA, Liu Y, March TH, Reed MD, et al. SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome. Int J Cancer [Internet]. 2014 Nov 1 [cited 2014 Nov 5];135(9):2223–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24668305

Filipczak P, Senft AP, Seagrave JC, Weber WM, Kuehl PJ, Fredenburgh LE, et al. Treatment of Lung Injury from Phosgene Chemical Inhalation with NOS-2 Inhibition. Society of Toxicology. Phoenix, AZ; 2014.

Kuehl PJ, Chand R, McDonald JD, Leach CL. Pulmonary deposition of FP/SX, FP and BCP - HFA pMDI’s via SPECT/CT imaging. Respiratory Drug Delivery2. Fajardo, Puerto Rico; 2014.

Wilder JA, Mega W, Sprague C, Hunzeker JT, Makvandi M, D’Egidio G, et al. Vaccine immunogenicity and efficacy of wild type and mutant (PA SNKE167-DFF-315-E308D) recombinant Bacillus Anthracis (rPA) molecules in a rabbit model of inhalational anthrax. ASM Biodefense and Emerging Diseases Research Meeting. Washington, DC; 2014.

Conway H, Dix KJ, McDonald JD, Miller RA, Wall HG, Wolff RK, et al. Comparison of inhalation toxicity studies of gentamicin in rats and dogs. Inhal Toxicol [Internet]. 2013 Nov [cited 2014 Feb 20];25(13):714–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24255949

Mapel DW, Roberts MH, Blanchette CM, Petersen H V, Ramachandran S. Effectiveness of inhaled combined corticosteroid/long acting bronchodilator treatment in reducing COPD exacerbations and short-acting bronchodilator use. J Clin Outcomes Manag. 2013;20(2):60–8 – 68.

Reed MD, Tellez CS, Grimes MJ, Picchi MA, Tessema M, Cheng YS, et al. Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model. Br J Cancer [Internet]. 2013 Oct 1 [cited 2013 Nov 21];109(7):1775–81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24045660

Roy CJ, Adams AP, Wang E, Leal G, Seymour RL, Sivasubramani SK, et al. A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus. Vaccine [Internet]. 2013 Mar 1 [cited 2014 Feb 20];31(11):1464–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23333212

Breit J, Vodak D, Kuehl PJ, Doyle-Eisele ML, Reed MD, Schachtner B. Pharmacokinetic analysis of an inhalable spray-dried engineered particle formulation of comptothecin for the treatment of lung cancer. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery 2012, vol 2. Raliegh, NC: Virginia Commonwealth University; 2012. p. 407–12.

Chand R, Kuehl PJ, Leach CL, McDonald JD. Radiolabeling validation of fluticasone propionate/salmeterol xinafoate-HFA pressurized metered dose inhaler. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery 2012, vol 2. Richmond VA: Virginia Commonwealth University; 2012. p. 573–6.

Corcoran TE, Devadason SG, Kuehl PJ. Introduction: Aerosol delivery of orally inhaled agents. J Aerosol Med Pulm Drug Deliv [Internet]. 2012 Dec [cited 2014 Feb 18];25 Suppl 1:S3–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23215846

Fleming J, Bailey DL, Chan H-K, Conway J, Kuehl PJ, Laube BL, et al. Standardization of techniques for using single-photon emission computed tomography (SPECT) for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv [Internet]. 2012 Dec [cited 2014 Feb 18];25 Suppl 1:S29–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23215845

Garcia A, Mack P, Williams S, Fromen C, Shen T, Tully J, et al. Microfabricated engineered particle systems for respiratory drug delivery and other pharmaceutical applications. J Drug Deliv [Internet]. 2012 Jan [cited 2014 Feb 3];2012:941243. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3307013&tool=pmcentrez&rendertype=abstract

Kuehl PJ, Anderson TL, Candelaria G, Gershman B, Harlin K, Hesterman JY, et al. Regional particle size dependent deposition of inhaled aerosols in rats and mice. Inhal Toxicol [Internet]. 2012 Jan [cited 2013 Sep 24];24(1):27–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22145784

Kuehl PJ, De S, Eppler B, Marsters J, Matthews L, Reed MD, et al. Development and validation of an HPLC assay for dual detection of gentamicin sulfate and leucine from a novel dry powder for inhalation. J Anal Bioanal Tech. 2012;3(6):1–4.

Leach CL, Kuehl PJ, Chand R, Ketai L, Norenberg JP, McDonald JD. Characterization of respiratory deposition of fluticasone-salmeterol hydrofluoroalkane-134a and hydrofluoroalkane-134a beclomethasone in asthmatic patients. Ann Allergy Asthma Immunol [Internet]. 2012 Mar [cited 2013 Sep 24];108(3):195–200. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22374204

Liu Y, Bernauer AM, Yingling CM, Belinsky SA. HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer. Carcinogenesis [Internet]. 2012 Jun [cited 2013 Sep 24];33(6):1187–92. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3388491&tool=pmcentrez&rendertype=abstract

Newman S, Bennett WD, Biddiscombe M, Devadason SG, Dolovich MB, Fleming J, et al. Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv [Internet]. 2012 Dec [cited 2014 Feb 18];25 Suppl 1:S10–28. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23215844

Reed MD, McCombie BE, Sivillo AE, Thorne PS, Welsh MJ, March TH, et al. Safety assessment of nebulized xylitol in beagle dogs. Inhal Toxicol [Internet]. 2012 May [cited 2013 Sep 24];24(6):365–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22564094

Seagrave JC, Albrecht HH, Hill DB, Rogers DF, Solomon G. Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. Respir Res [Internet]. 2012 Jan [cited 2013 Sep 17];13:98. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3545908&tool=pmcentrez&rendertype=abstract

Shankar GN, Weber WM, Doyle-Eisele ML, Guilmette RA. Efficacy of a novel orally administered formulation of DTPA tablets for decorporating an intravenously injected radionuclide: a comparison with intravenously administered licensed DTPA. Drug Dev Res. 2012;73(5):290–8.

Devadason SG, Chan H-K, Haeussermann S, Kietzig C, Kuehl PJ, Newman S, et al. Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv [Internet]. 2012 Dec [cited 2014 Feb 18];25 Suppl 1:S6–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23215848

Belinsky SA, Grimes MJ, Picchi MA, Mitchell HD, Stidley CA, Tesfaigzi Y, et al. Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res [Internet]. 2011 Jan 15 [cited 2013 Sep 24];71(2):454–62. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3075424&tool=pmcentrez&rendertype=abstract

Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, et al. A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell [Internet]. 2011 Jun 10 [cited 2013 Sep 24];42(5):597–609. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3138416&tool=pmcentrez&rendertype=abstract

Chulay JD, Ye G-J, Thomas DL, Knop DR, Benson JM, Hutt JA, et al. Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method. Hum Gene Ther [Internet]. 2011 Feb [cited 2013 Sep 19];22(2):155–65. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3042310&tool=pmcentrez&rendertype=abstract

Dalal AA, Roberts MH, Petersen H V, Blanchette CM, Mapel DW. Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis [Internet]. 2011 Jan [cited 2013 Sep 24];6:13–22. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3034283&tool=pmcentrez&rendertype=abstract

Feng AL, Boraey MA, Gwin MA, Finlay PR, Kuehl PJ, Vehring R. Mechanistic models facilitate efficient development of leucine containing microparticles for pulmonary drug delivery. Int J Pharm [Internet]. 2011 May 16 [cited 2013 Sep 24];409(1-2):156–63. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21356284

Jiang X, Cheng YS, Smyth HDC. Nanostructured Aerosol Particles: Fabrication, Pulmonary Drug Delivery, and Controlled Release. J Nanomater. 2011;article ID 198792.

Kuehl PJ. Imaging pulmonary drug delivery. In: Smyth HDC, Hickey A, editors. Controlled Pulmonary Drug Delivery. New York, NY: Springer; 2011. p. 475–87.

Layton RC, Mega W, McDonald JD, Brasel TL, Barr EB, Gigliotti AP, et al. Levofloxacin cures experimental pneumonic plague in African green monkeys. PLoS Negl Trop Dis [Internet]. 2011 Jan [cited 2013 Sep 24];5(2):e959. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3035670&tool=pmcentrez&rendertype=abstract

Roberts MH, Mapel DW, Petersen H V, Blanchette CM, Ramachandran S. Comparative effectiveness of budesonide/formoterol and fluticasone/salmeterol for COPD management. J Med Econ [Internet]. 2011 Jan [cited 2014 Jan 29];14(6):769–76. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21942463

Seagrave JC, Albrecht HH, Park YS, Rubin B, Solomon G, Kim KC. Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res [Internet]. 2011 Dec [cited 2013 Sep 24];37(10):606–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22044398

Silver HS, Blanchette CM, Kamble S, Petersen H V, Letter MA, Meddis D, et al. Relationship between short-acting β2-adrenergic agonist use and healthcare costs. Am J Manag Care [Internet]. 2011 Jan [cited 2013 Sep 24];17(1):19–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21348565

Smith KR, Leonard D, McDonald JD, Tesfaigzi Y. Inflammation, mucous cell metaplasia, and Bcl-2 expression in response to inhaled lipopolysaccharide aerosol and effect of rolipram. Toxicol Appl Pharmacol [Internet]. 2011 Jun 15 [cited 2013 Sep 24];253(3):253–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3103593&tool=pmcentrez&rendertype=abstract

Vodak D, Dobry D, Friesen DT, Reed MD, Gigliotti AP, Kuehl PJ, et al. Dextran-based materials as excipients in engineered particle formulations: tailoring physical properties to optimize performance, manufacturability, and safety. In: Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ, Yound PM, editors. Proceedings of Respiratory Drug Delivery. Richmond VA: Virginia Commonwealth University; 2011. p. 1–9.

Zhuang J, Xu J, Zhang C, Xu F. IL-1β acutely increases pulmonary SP and permeability without associated changes in airway resistance and ventilation in anesthetized rats. Respir Physiol Neurobiol [Internet]. 2011 Jan 31 [cited 2013 Sep 27];175(1):12–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20692381

Aillon KL, El-Gendy N, Dennis C, Norenberg JP, McDonald JD, Berkland C. Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization. Mol Pharm [Internet]. 2010 Aug 2 [cited 2014 Feb 20];7(4):1274–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20575527

Dalal AA, St Charles M, Petersen H V, Roberts MH, Blanchette CM, Manavi-Zieverink K. Cost-effectiveness of combination fluticasone propionate-salmeterol 250/50 microg versus salmeterol in severe COPD patients. Int J Chron Obstruct Pulmon Dis [Internet]. 2010 Jan [cited 2013 Sep 27];5:179–87. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2921685&tool=pmcentrez&rendertype=abstract

Kuehl PJ, Barrett EG, McDonald JD, Rudolph K, Vodak D, Dobry D, et al. Formulation development and in vivo evaluation of a new dry powder formulation of albuterol sulphate in beagle dogs. Pharm Res [Internet]. 2010 May [cited 2013 Sep 30];27(5):894–904. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20232119

Kuehl PJ, Belinsky SA, Chand R, Channell MM, Lucak J, McDonald JD, et al. Pharmacokinetic comparison and analysis of aqueous and dry powder inhalation formulations of 5-azacytidine. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 2. Richmond VA: Virginia Commonwealth University; 2010. p. 627–31.

Mapel DW, Hurley JS, Dalal AA, Blanchette CM. The role of combination inhaled corticosteroid/long-acting beta-agonist therapy in COPD management. Prim Care Respir J [Internet]. 2010 Jun [cited 2013 Sep 30];19(2):93–103. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20339822

Mitchell LA, Channell MM, Royer CM, Ryter SW, Choi AMK, McDonald JD. Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation. Am J Physiol Lung Cell Mol Physiol [Internet]. 2010 Dec [cited 2013 Sep 30];299(6):L891–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20729385

Silver HS, Blanchette CM, Kamble S, Petersen H V, Letter MA, Meddis D, et al. Quarterly assessment of short-acting beta(2)-adrenergic agonist use as a predictor of subsequent health care use for asthmatic patients in the United States. J Asthma [Internet]. 2010 Aug [cited 2013 Sep 30];47(6):660–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20615167

Talton J, Eppler J, Kirk B, Hammond L, Matthews L, Dungan N, et al. Inhaled Gentamicin: making a dry powder formulation to satisfy a clinical need. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 2. Richmond VA: Virginia Commonwealth University; 2010. p. 63–72.

Vodak D, Dobry D, Kuehl PJ, Barrett EG, Rudolph K, McDonald JD, et al. Assessment of lung function in a ragweed challenge dog model after inhalation of engineered particle formulation of albuterol sulfate. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery, Vol 22. Richmond VA: Virginia Commonwealth University; 2010. p. 431–4.

Blanchette CM, Joshi A V, Szpalski M, Gunzburg R, Du Bois M, Donceel P, et al. Burden of blood transfusion in knee and hip surgery in the US and Belgium. J Med Econ [Internet]. 2009 Sep [cited 2013 Sep 30];12(3):171–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19622009

Blanchette CM, Mapel DW, Petersen H V, Drelick A, Charles MS, Ramachandran S. RELATIONSHIP BETWEEN EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND DURATION OF CONTROLLER THERAPY AMONG A COMMERCIALLY INSURED POPULATION IN THE UNITED STATES. Value Health. 2009;12(3):A121.

Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, et al. Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine. J Pharmacol Exp Ther [Internet]. 2009 Mar [cited 2013 Sep 30];328(3):970–5. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3202424&tool=pmcentrez&rendertype=abstract

Edgerton DS, Johnson KMS, Neal DW, Scott M, Hobbs CH, Zhang X, et al. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog. Diabetes [Internet]. 2009 Jan [cited 2013 Sep 30];58(1):243–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2606880&tool=pmcentrez&rendertype=abstract

Kuehl PJ, Stratton SP, Powell MB, Myrdal PB. Preformulation, formulation, and in vivo efficacy of topically applied apomine. Int J Pharm [Internet]. 2009 Dec 1 [cited 2013 Oct 1];382(1-2):104–10. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2783960&tool=pmcentrez&rendertype=abstract

Leach CL, Colice GL, Luskin A. Particle size of inhaled corticosteroids: does it matter? J Allergy Clin Immunol [Internet]. 2009 Dec [cited 2013 Oct 3];124(6 Suppl):S88–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19962042

Lin H-L, Fink JB, Zhou Y, Cheng YS. Influence of moisture accumulation in inline spacer on delivery of aerosol using metered-dose inhaler during mechanical ventilation. Respir Care [Internet]. 2009 Oct [cited 2013 Oct 7];54(10):1336–41. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19796413

Renne R, Brix A, Harkema JR, Herbert R, Kittel B, Lewis D, et al. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol [Internet]. 2009 Dec [cited 2013 Oct 7];37(7 Suppl):5S – 73S. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20032296

Su W-C, Cheng YS. Deposition of man-made fibers in human respiratory airway casts. Soto A, Salazar G, editors. Asbestos Risk Environ Impact. New York, NY: Nova Science Publishers; 2009;40(3):270–84.

Vodak D, Dobry D, Kuehl PJ, Doyle-Eisele ML, McDonald JD, Silcock A, et al. Platform formulation development utilizing a novel pulmonary excipient and in vivo evaluation of engineered particles of fluticasone propionate as a model formulation. In: Dalby R, Byron P, Peart J, Duman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery 2009 Vol 2. Richmond VA: Virginia Commonwealth University; 2009. p. 251–4.

Ye X, Gutierrez B, Zarotsky V, Nelson M, Blanchette CM. Appropriate use of inhaled corticosteroid and long-acting beta(2)-adrenergic agonist combination therapy among asthma patients in a US commercially insured population. Curr Med Res Opin [Internet]. 2009 Sep [cited 2013 Oct 11];25(9):2251–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19622006

Akazawa M, Hayflinger DC, Stanford RH, Blanchette CM. Economic assessment of initial maintenance therapy for chronic obstructive pulmonary disease. Am J Manag Care [Internet]. 2008 Jul [cited 2013 Oct 11];14(7):438–48. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18611095

Blanchette CM, Akazawa M, Dalal AA, Simoni-Wastila L. Risk of hospitalizations/emergency department visits and treatment costs associated with initial maintenance therapy using fluticasone propionate 500 microg/salmeterol 50 microg compared with ipratropium for chronic obstructive pulmonary disease in older. Am J Geriatr Pharmacother [Internet]. 2008 Aug [cited 2013 Oct 11];6(3):138–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18775388

Blanchette CM, Gutierrez B, Ory C, Chang E, Akazawa M. Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population. J Manag Care Pharm [Internet]. 2008 Mar [cited 2013 Oct 11];14(2):176–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18331119

Blanchette CM, Simoni-Wastila L, Zuckerman IH, Stuart B. A secondary analysis of a duration response association between selective serotonin reuptake inhibitor use and the risk of acute myocardial infarction in the aging population. Ann Epidemiol [Internet]. 2008 Apr [cited 2013 Oct 11];18(4):316–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18261924

Cheng YS, Irshad H, Kuehl PJ, Holmes TD, Sherwood RL, Hobbs CH. Lung deposition of droplet aerosols in monkeys. Inhal Toxicol [Internet]. 2008 Sep [cited 2013 Oct 11];20(11):1029–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18720170

Kuehl PJ, Brenner T, Jain PK, Karlage K, Sepassi K, Yang G, et al. Formulation and in vivo evaluation of chlorpropham (CIPC) oral formulations. J Pharm Sci [Internet]. 2008 Dec [cited 2013 Oct 11];97(12):5222–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18383335

Kuehl PJ, Cheng YS, Holmes TD, Irshad H, Leach CL, McDonald JD. Regional deposition analysis of a Technetium-99m labeled aerosol to anesthetized non human primates by planar gamma camera imaging. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery Vol 2. Richmond VA: Virginia Commonwealth University; 2008. p. 601–4.

Kuehl PJ, Karlage K, Brenner T, Myrdal PB. Determining the effect of Carbendazim and Paclitaxel, dosed orally and via inhalation, on pulmonary adenomas in the A/J mouse model. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery Vol 2. Richmond VA: Virginia Commonwealth University; 2008. p. 605–10.

Lin Y, Shi R, Wang X, Shen H-M. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets [Internet]. 2008 Nov [cited 2013 Oct 14];8(7):634–46. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2615542&tool=pmcentrez&rendertype=abstract

Shanley KT, Zamankhan P, Ahmadi G, Hopke PK, Cheng YS. Numerical simulations investigating the regional and overall deposition efficiency of the human nasal cavity. Inhal Toxicol [Internet]. 2008 Sep [cited 2013 Oct 14];20(12):1093–100. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18800272

Chan SSL, Santos JH, Meyer JN, Mandavilli BS, Cook DL, McCash CL, et al. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ Mol Mutagen [Internet]. 2007 [cited 2013 Oct 14];48(3-4):190–200. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16395692

Escobar PA, Olivero OA, Wade NA, Abrams EJ, Nesel CJ, Ness RB, et al. Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. Environ Mol Mutagen [Internet]. 2007 [cited 2013 Oct 14];48(3-4):330–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17358027

Fadl A, Wang J, Yang P, Zhang Z, Cheng YS. Balloon-based in vitro MDI aerosol deposition experiments on the effects of mouthpiece diameter. Inhal Toxicol [Internet]. 2007 May [cited 2013 Oct 14];19(6-7):505–15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17497529

Fadl A, Wang J, Zhang Z, Cheng YS. Effects of MDI spray angle on aerosol penetration efficiency through an oral airway cast. J Aerosol Sci. 2007;38(8):853–64.

Foo MY, Cheng YS, Su W-C, Donovan MD. The influence of spray properties on intranasal deposition. J Aerosol Med [Internet]. 2007 Jan [cited 2013 Oct 14];20(4):495–508. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18158721

Leach CL. Inhalation aspects of therapeutic aerosols. Toxicol Pathol [Internet]. 2007 Jan [cited 2013 Oct 14];35(1):23–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17325969

Roller CM, Zhang G, Troedson RG, Leach CL, Le Souëf PN, Devadason SG. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur Respir J [Internet]. 2007 Feb [cited 2013 Oct 14];29(2):299–306. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17005581

Rowan WH, Campen MJ, Wichers LB, Watkinson WP. Heart rate variability in rodents: uses and caveats in toxicological studies. Cardiovasc Toxicol [Internet]. 2007 Jan [cited 2013 Oct 14];7(1):28–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17646680

Zhou Y, Brasel TL, Kracko DA, Cheng YS, Ahuja A, Norenberg JP, et al. Influence of impactor operating flow rate on particle size distribution of four jet nebulizers. Pharm Dev Technol [Internet]. 2007 Jan [cited 2013 Oct 18];12(4):353–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17763140

Edgerton DS, Cherrington AD, Williams P, Neal DW, Scott M, Bowen LE, et al. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Diabetes [Internet]. 2006 Dec [cited 2013 Oct 21];55(12):3604–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17130510

Edgerton DS, Stettler KM, Neal DW, Scott M, Bowen LE, Wilson W, et al. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. J Pharmacol Exp Ther [Internet]. 2006 Dec [cited 2013 Oct 21];319(3):1258–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16963622

Enger SM, Thwin SS, Buist DSM, Field TS, Frost FJ, Geiger AM, et al. Breast cancer treatment of older women in integrated health care settings. J Clin Oncol [Internet]. 2006 Sep 20 [cited 2013 Oct 21];24(27):4377–83. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1913483&tool=pmcentrez&rendertype=abstract

Heynekamp JJ, Weber WM, Hunsaker LA, Gonzales AM, Orlando RA, Deck LM, et al. Substituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J Med Chem [Internet]. 2006 Nov 30 [cited 2013 Oct 21];49(24):7182–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17125270

Leach CL, Bethke TD, Boudreau RJ, Hasselquist BE, Drollmann A, Davidson P, et al. Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteers. J Aerosol Med [Internet]. 2006 Jan [cited 2013 Oct 21];19(2):117–26. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16796536

Leach CL, LeSouef P. Mometasone and beclomethasone comparison article observations. Chest [Internet]. 2006 May [cited 2013 Oct 21];129(5):1389–90; author reply 1390–1. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16685036

Environmental Toxicology

Garner CE, Liang S, Yin L, Yu X. Physiologically based pharmacokinetic modeling for 1-bromopropane in F344 rats using gas uptake inhalation experiments. Toxicol Sci [Internet]. 2015 Jan 28 [cited 2015 Feb 2]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25634537

Yu R, Lai Y, Hartwell HJ, Moeller BC, Doyle-Eisele M, Kracko D, et al. Formation, Accumulation and Hydrolysis of Endogenous and Exogenous Formaldehyde Induced DNA Damage. Toxicol Sci [Internet]. 2015 Apr 21 [cited 2015 May 4]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25904104

Mauderly JL. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: I. Background, experimental strategy and critique. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 8];26(11):643–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162718

Mauderly JL, Barrett EG, Day KC, Gigliotti AP, McDonald JD, Harrod KS, et al. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 9];26(11):651–67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162719

Mauderly JL, Kracko DA, Brower J, Doyle-Eisele ML, McDonald JD, Lund AK, et al. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 9];26(11):691–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162721

Mauderly JL, Seilkop SK. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: III. Components of diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions driving non-cancer biological resp. Inhal Toxicol [Internet]. 2014 Sep [cited 2014 Sep 9];26(11):668–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25162720

McDonald JD, Kracko DA, Doyle-Eisele ML, Garner CE, Wegerski CJ, Senft AP, et al. Carbon Capture and Sequestration: An Exploratory Inhalation Toxicity Assessment of Amine-Trapping Solvents and Their Degradation Products. Environ Sci Technol [Internet]. 2014 Aug 28 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25167095

Nakamura J, Mutlu E, Sharma V, Collins L, Bodnar W, Yu R, et al. The endogenous exposome. DNA Repair (Amst) [Internet]. 2014 Jul [cited 2015 Mar 9];19:3–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24767943

Su W-C, Cheng YS. Carbon nanotubes size classification, characterization and nasal airway deposition. Inhal Toxicol [Internet]. 2014 Oct 7 [cited 2014 Nov 5];1–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25289729

Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, et al. Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) γ Methylation in Offspring, Grand-Offspring Mice. PLoS One [Internet]. 2014 Jan [cited 2014 Nov 5];9(10):e110706. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4210202&tool=pmcentrez&rendertype=abstract

Zhou Y, Guo M, Xi J, Irshad H, Cheng Y-S. Nasal deposition in infants and children. J Aerosol Med Pulm Drug Deliv [Internet]. 2014 Apr [cited 2015 May 4];27(2):110–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23586501

Zhou Y, Irshad H, Tsai C-J, Hung S-M, Cheng YS. Evaluation of a novel personal nanoparticle sampler. Environ Sci Process Impacts [Internet]. 2014 Jan [cited 2014 Sep 9];16(2):203–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24337074

Awji EG, Chand HS, Bruse SE, Smith KR, Colby JK, Mebratu YA, et al. Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells. Am J Respir Cell Mol Biol [Internet]. 2014 Aug 19 [cited 2014 Sep 9]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25137396

Brower J, Moeller BC, Doyle-Eisele ML, McDonald JD, Stirdivant S, Campen MJ. Acute Inhalation Exposure to Mixed Vehicle Emissions Induces Serum Metabolite Changes Related to Oxidative Stress, Lipid Peroxidation, and Energy Metabolism. Society of Toxicology. Phoenix, AZ; 2014.

Doyle-Eisele ML, Rohr AC, Knipping EM, Lund AK, Brower J, McDonald JD. Secondary Organic Aerosols Generated from α-Pinene-Amine Mixtures: Effects on the Cardiovascular System. Society of Toxicology. Phoenix, AZ; 2014.

Filipczak P, Senft AP, Seagrave JC, Weber WM, Kuehl PJ, Fredenburgh LE, et al. Treatment of Lung Injury from Phosgene Chemical Inhalation with NOS-2 Inhibition. Society of Toxicology. Phoenix, AZ; 2014.

Kracko DA, Wegerski CJ, McDonald JD, Doyle-Eisele ML, Shaw S, Knipping EM, et al. Pulmonary Toxicity of Oxygen and Carbon Dioxide Degraded Amines Used for Carbon Capture and Storage. Society of Toxicology. Phoenix, AZ; 2014.

McDonald JD, Mauderly JL, Miller RA, Seilkop SK, Seagrave JC, Gigliotti AP, et al. ACES Phase 3: Results from lifetime studies in rats exposed to 2007 compliant diesel emissions. Society of Toxicology. Phoenix, AZ; 2014.

Moeller BC, Bodnar W, Collins L, Swenberg JA. Measurement of endogenous and exogenous 1,N2-propano-dG DNA adducts by liquid chromatography - tandem mass spectrometry. Society of Toxicology. Phoenix, AZ; 2014.

Cheng YS, Su W-C. Thoracic fraction of inhaled fiber aerosol. J Occup Environ Hyg. 2013;10(4):194–202.

Chu S, Zhang H, Maher C, McDonald JD, Zhang X, Ho S-M, et al. Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring. J Toxicol [Internet]. 2013 Jan [cited 2014 Feb 4];2013:603581. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3876588&tool=pmcentrez&rendertype=abstract

Lund AK, Doyle-Eisele ML, Lin Y-H, Arashiro M, Surratt JD, Holmes TD, et al. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhal Toxicol [Internet]. 2013 May [cited 2013 Sep 19];25(6):309–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23742109

McDonald JD, Chow JC, Peccia J, Liu Y, Chand R, Hidy GM, et al. Influence of collection region and site type on the composition of paved road dust. Air Qual Atmos Heal. 2013;6(3):615–28.

Oppenheim HA, Lucero J, Guyot A-C, Herbert LM, McDonald JD, Mabondzo A, et al. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Part Fibre Toxicol [Internet]. 2013 Jan [cited 2013 Dec 21];10(1):62. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3878624&tool=pmcentrez&rendertype=abstract

Rager JE, Moeller BC, Doyle-Eisele ML, Kracko DA, Swenberg JA, Fry RC. Formaldehyde and epigenetic alterations: microRNA changes in the nasal epithelium of nonhuman primates. Environ Health Perspect [Internet]. 2013 Mar [cited 2014 Feb 17];121(3):339–44.

Sood A, Qualls C, Seagrave JC, McDonald JD, Shohreh R, Chiavaroli A, et al. Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma. J Asthma [Internet]. 2013 Jun [cited 2014 Feb 20];50(5):449–56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23461590

Zhou Y, Xi J, Simpson J, Irshad H, Cheng YS. Aerosol deposition in a nasopharyngolaryngeal replica of a 5-year-old child. Aerosol Sci Technol. 2013;43(3):275–82.

Ayala A, Brauer M, Mauderly JL, Samet JM. Air pollutants and sources associated with health effects. Air Qual Atmos Heal. 2012;5(2):151–67.

Bachand GD, Allen A, Bachand M, Achyuthan KE, Seagrave JC, Brozik SM. Cytotoxicity and inflammation in human alveolar epithelial cells following exposure to occupational levels of gold and silver nanoparticles. J Nanoparticle Res. 2012;14:1212.

Farfán EB, Labone TR, Staack GC, Cheng YS, Zhou Y, Varallo TP. Determination of in vitro lung solubility and intake-to-dose conversion factor for tritiated lanthanum nickel aluminum alloy. Health Phys [Internet]. 2012 Sep [cited 2014 Feb 17];103(3):249–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22850229

Farfán EB, Labone TR, Staack GC, Cheng YS, Zhou Y, Varallo TP. Determination of in vitro lung solubility and intake-to-dose conversion factor for tritiated lanthanum nickel aluminum alloy. Health Phys [Internet]. 2012 Sep [cited 2014 Feb 17];103(3):249–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22850229

Jiang X, Bao L, Cheng YS, Dunphy DR, Li X, Brinker CJ. Aerosol-assisted synthesis of monodisperse single-crystalline α-cristobalite nanospheres. Chem Commun (Cambridge, England)2. 2012;48(9):1293–5.

Kreider ML, Doyle-Eisele ML, Russell RG, McDonald JD, Panko JM. Evaluation of potential for toxicity from subacute inhalation of tire and road wear particles in rats. Inhal Toxicol [Internet]. 2012 Nov [cited 2014 Feb 17];24(13):907–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23121300

Kuehl PJ, Anderson TL, Candelaria G, Gershman B, Harlin K, Hesterman JY, et al. Regional particle size dependent deposition of inhaled aerosols in rats and mice. Inhal Toxicol [Internet]. 2012 Jan [cited 2013 Sep 24];24(1):27–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22145784

McDonald JD, Doyle-Eisele ML, Gigliotti AP, Miller RA, Seilkop SK, Mauderly JL, et al. Part 1. Biologic responses in rats and mice to subchronic inhalation of diesel exhaust from U.S. 2007-compliant engines: report on 1-, 3-, and 12-month exposures in the ACES bioassay. Res Rep Health Eff Inst [Internet]. 2012 Sep [cited 2013 Sep 24];(166):9–120. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23156840

McDonald JD, Doyle-Eisele ML, Kracko DA, Lund AK, Surratt JD, Hersey SP, et al. Cardiopulmonary response to inhalation of secondary organic aerosol derived from gas-phase oxidation of toluene. Inhal Toxicol [Internet]. 2012 Sep [cited 2013 Sep 17];24(11):689–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22954394

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Mauderly JL, Garshick E. Diesel Exhaust. In: Lippmann M, editor. Environmental Toxicants: Human Exposures and Their Health Effects. New York, NY: Wiley-Interscience; 2009. p. 551–631.

Mauderly JL, Samet JM. Is there evidence for synergy among air pollutants in causing health effects? Environ Health Perspect [Internet]. 2009 Jan [cited 2013 Oct 7];117(1):1–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2627851&tool=pmcentrez&rendertype=abstract

Mitchell LA, Lauer FT, Burchiel SW, McDonald JD. Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice. Nat Nanotechnol [Internet]. 2009 Jul [cited 2013 Oct 7];4(7):451–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3641180&tool=pmcentrez&rendertype=abstract

Morishita M, Keeler GJ, McDonald JD, Wagner JG, Young L-H, Utsunomiya S, et al. Source-to-receptor pathways of anthropogenic PM2.5 in Detroit, Michigan: comparison of two inhalation exposure studies. Atmos Environ. 2009;43(10):1805–13.

Renne R, Brix A, Harkema JR, Herbert R, Kittel B, Lewis D, et al. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol [Internet]. 2009 Dec [cited 2013 Oct 7];37(7 Suppl):5S – 73S. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20032296

Su W-C, Cheng YS. Deposition of man-made fibers in human respiratory airway casts. Soto A, Salazar G, editors. Asbestos Risk Environ Impact. New York, NY: Nova Science Publishers; 2009;40(3):270–84.

Walker VE, Walker DM, Meng Q, McDonald JD, Scott BR, Seilkop SK, et al. Genotoxicity of 1,3-butadiene and its epoxy intermediates. Res Rep Health Eff Inst [Internet]. 2009 Aug [cited 2013 Oct 7];(144):3–79. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20017413

Lund AK, Lucero J, Lucas SN, Madden MC, McDonald JD, Seagrave JC, et al. Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways. Arterioscler Thromb Vasc Biol [Internet]. 2009 Apr [cited 2013 Oct 7];29(4):511–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19150882

Aragon AC, Kopf PG, Campen MJ, Huwe JK, Walker MK. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol Sci [Internet]. 2008 Feb [cited 2013 Oct 11];101(2):321–30. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3613251&tool=pmcentrez&rendertype=abstract

Backer LC, Carmichael W, Kirkpatrick B, Williams C, Irvin CM, Zhou Y, et al. Recreational exposure to low concentrations of microcystins during an algal bloom in a small lake. Mar Drugs [Internet]. 2008 Jan [cited 2013 Oct 11];6(2):389–406. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2525495&tool=pmcentrez&rendertype=abstract

Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ, et al. Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regul Toxicol Pharmacol [Internet]. 2008 Jul [cited 2013 Oct 11];51(2 Suppl):S27–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18191315

Braun A, Huggins F, Kubátová A, Wirick S, Maricq M, Mun B, et al. Toward distinguishing woodsmoke and diesel exhaust in ambient particulate matter. Environ Sci Technol [Internet]. 2008 Jan 15 [cited 2013 Oct 11];42(2):374–80. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18284133

Cheng YS, Irshad H, Kuehl PJ, Holmes TD, Sherwood RL, Hobbs CH. Lung deposition of droplet aerosols in monkeys. Inhal Toxicol [Internet]. 2008 Sep [cited 2013 Oct 11];20(11):1029–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18720170

Day KC, Reed MD, McDonald JD, Seilkop SK, Barrett EG. Effects of gasoline engine emissions on preexisting allergic airway responses in mice. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 11];20(13):1145–55. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18951231

Hedtke B, Gao Z, Chen L-J, Weber WM, Dix KJ. Metabolism and disposition of [14C]5-amino-o-cresol in female F344 rats and B6C3F1 mice. Xenobiotica [Internet]. 2008 Feb [cited 2013 Oct 11];38(2):171–84. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18197558

Knuckles TL, Lund AK, Lucas SN, Campen MJ. Diesel exhaust exposure enhances venoconstriction via uncoupling of eNOS. Toxicol Appl Pharmacol [Internet]. 2008 Aug 1 [cited 2013 Oct 11];230(3):346–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18455212

Kozisek F, Craun GF, Cerovska L, Pumann P, Frost FJ, Muller TB. Serological responses to Cryptosporidium-specific antigens in Czech populations with different water sources. Epidemiol Infect [Internet]. 2008 Feb [cited 2013 Oct 11];136(2):279–86. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2870799&tool=pmcentrez&rendertype=abstract

Kuehl PJ, Cheng YS, Holmes TD, Irshad H, Leach CL, McDonald JD. Regional deposition analysis of a Technetium-99m labeled aerosol to anesthetized non human primates by planar gamma camera imaging. In: Dalby R, Byron P, Peart J, Suman J, Farr S, Young P, editors. Proceedings of Respiratory Drug Delivery Vol 2. Richmond VA: Virginia Commonwealth University; 2008. p. 601–4.

LeClaire RD, Millard C. Ricin and related toxins: review and perspective. In: Romano JJ, Lukey B, Salem H, editors. Chemical warfare agents: chemistry, pharmacology, toxicology and therapeutics. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2008. p. 423–68.

Leng S, Stidley CA, Bernauer AM, Picchi MA, Sheng X, Frasco MA, et al. Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. Carcinogenesis [Internet]. 2008 Jul [cited 2013 Oct 14];29(7):1380–5. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2899849&tool=pmcentrez&rendertype=abstract

Mauderly JL, Chow JC. Health effects of organic aerosols. Inhal Toxicol [Internet]. 2008 Feb [cited 2013 Oct 14];20(3):257–88. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18300047

McDonald JD, Barr EB, White RK, Kracko DA, Chow JC, Zielinska B, et al. Generation and characterization of gasoline engine exhaust inhalation exposure atmospheres. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 14];20(13):1157–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18951232

North DW, Abdo KM, Benson JM, Dahl AR, Morris JB, Renne R, et al. A review of whole animal bioassays of the carcinogenic potential of naphthalene. Regul Toxicol Pharmacol [Internet]. 2008 Jul [cited 2013 Oct 14];51(2 Suppl):S6–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18364246

Reed MD, Barrett EG, Campen MJ, Divine KK, Gigliotti AP, McDonald JD, et al. Health effects of subchronic inhalation exposure to gasoline engine exhaust. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 14];20(13):1125–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18800271

Seagrave JC. Mechanisms and implications of air pollution particle associations with chemokines. Toxicol Appl Pharmacol [Internet]. 2008 Nov 1 [cited 2013 Sep 19];232(3):469–77. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2585747&tool=pmcentrez&rendertype=abstract

Seagrave JC, Campen MJ, McDonald JD, Mauderly JL, Rohr AC. Oxidative stress, inflammation, and pulmonary function assessment in rats exposed to laboratory-generated pollutant mixtures. J Toxicol Environ Health A [Internet]. 2008 Jan [cited 2013 Oct 14];71(20):1352–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18704828

Shanley KT, Zamankhan P, Ahmadi G, Hopke PK, Cheng YS. Numerical simulations investigating the regional and overall deposition efficiency of the human nasal cavity. Inhal Toxicol [Internet]. 2008 Sep [cited 2013 Oct 14];20(12):1093–100. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18800272

Su W-C, Wu J, Marijnissen JC, Cheng YS. Deposition of Man-Made Fibers in a Human Nasal Airway. Aerosol Sci Technol. 2008;42(3):173–81.

Weber WM, Marr R, Kracko DA, Gao Z, McDonald JD, Chearnaigh KU. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxciology Environ Chem. 2008;90(3):445–55.

Zhou Y, Su W-C, Cheng YS. Fiber deposition in the tracheobronchial region: deposition equations. Inhal Toxicol [Internet]. 2008 Oct [cited 2013 Oct 11];20(13):1191–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18951234

Zhuang J, Xu F, Campen MJ, Zhang C, Pena-Philippides JC, Sopori ML. Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats. Toxicol Appl Pharmacol [Internet]. 2008 Nov 1 [cited 2013 Oct 14];232(3):440–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3466117&tool=pmcentrez&rendertype=abstract

Albertini RJ, Sram RJ, Vacek PM, Lynch J, Rossner P, Nicklas JA, et al. Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons. Chem Biol Interact [Internet]. 2007 Mar 20 [cited 2013 Oct 14];166(1-3):63–77. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16949064

Boysen G, Georgieva NI, Upton PB, Walker VE, Swenberg JA. N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides. Chem Biol Interact [Internet]. 2007 Mar 20 [cited 2013 Oct 14];166(1-3):84–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17084829

Bredow S, Falgout MM, March TH, Yingling CM, Malkoski SP, Aden JK, et al. Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs. Toxicol Appl Pharmacol [Internet]. 2007 Jun 1 [cited 2013 Oct 14];221(2):148–57. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2478672&tool=pmcentrez&rendertype=abstract

Cheng YS, Zhou Y, Irvin CM, Kirkpatrick B, Backer LC. Characterization of aerosols containing microcystin. Mar Drugs [Internet]. 2007 Jan [cited 2013 Oct 14];5(4):136–50. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2365700&tool=pmcentrez&rendertype=abstract

Dix KJ, Ghanbari K, Hedtke-Weber BM. Disposition of [14C]N,N-dimethyl-p-toluidine in F344 rats and B6C3F1 mice. J Toxicol Environ Health A [Internet]. 2007 May 15 [cited 2013 Oct 14];70(10):789–98. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17454555

Ferguson L-JC, Lebetkin EH, Lih FB, Tomer KB, Parkinson HD, Borghoff SJ, et al. 14C-labeled pulegone and metabolites binding to alpha2u-globulin in kidneys of male F-344 rats. J Toxicol Environ Health A [Internet]. 2007 Sep [cited 2013 Oct 14];70(17):1416–23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17687727

Fleming LE, Kirkpatrick B, Backer LC, Bean JA, Wanner A, Reich A, et al. Aerosolized red-tide toxins (brevetoxins) and asthma. Chest [Internet]. 2007 Jan [cited 2013 Oct 14];131(1):187–94. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2683400&tool=pmcentrez&rendertype=abstract

Goggin M, Loeber R, Park S, Walker VE, Wickliffe J, Tretyakova N. HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chem Res Toxicol [Internet]. 2007 May [cited 2013 Oct 14];20(5):839–47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17455958

Gold K, Cheng YS, Holmes TD. A quantitative analysis of aerosols inside an armored vehicle perforated by a kinetic energy penetrator containing tungsten, nickel, and cobalt. Mil Med [Internet]. 2007 Apr [cited 2013 Oct 14];172(4):393–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17484310

Green FHY, Vallyathan V, Hahn FF. Comparative pathology of environmental lung disease: an overview. Toxicol Pathol [Internet]. 2007 Jan [cited 2013 Oct 14];35(1):136–47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17325982

Henderson RF, Gurule M, Hedtke-Weber BM, Ghanbari K, McDonald JD, Kracko DA, et al. Disposition of orally and intravenously administered methyltetrahydrofuran in rats and mice. J Toxicol Environ Health A [Internet]. 2007 Apr 1 [cited 2013 Oct 14];70(7):582–93. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17365612

Kim N-C, Ghanbari K, Kracko DA, Weber WM, McDonald JD, Dix KJ. Identification of urinary metabolites of orally administered N,N-dimethyl-p-toluidine in male F344 rats. J Toxicol Environ Health A [Internet]. 2007 May 15 [cited 2013 Oct 14];70(10):781–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17454554

Lund AK, Knuckles TL, Obot Akata CJ, Shohet R V, McDonald JD, Gigliotti AP, et al. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci [Internet]. 2007 Feb [cited 2013 Oct 14];95(2):485–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17065432

McDonald JD, Reed MD, Campen MJ, Barrett EG, Seagrave JC, Mauderly JL. Health effects of inhaled gasoline engine emissions. Inhal Toxicol [Internet]. 2007 Jan [cited 2013 Oct 14];19 Suppl 1:107–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17886058

McDonald JD, Weber WM, Marr R, Kracko DA, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A [Internet]. 2007 May 15 [cited 2013 Oct 14];70(10):829–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17454559

Meng Q, Redetzke DL, Hackfeld LC, Hodge RP, Walker DM, Walker VE. Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphblastoid cells. Chem Biol Interact [Internet]. 2007 Mar 20 [cited 2013 Oct 14];166(1-3):207–18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16854403

Meng Q, Walker DM, McDonald JD, Henderson RF, Carter MM, Cook DL, et al. Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene. Chem Biol Interact [Internet]. 2007 Mar 20 [cited 2013 Oct 14];166(1-3):121–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16945358

Mitchell LA, Gao J, Wal R Vander, Gigliotti AP, Burchiel SW, McDonald JD. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol Sci [Internet]. 2007 Nov [cited 2013 Oct 14];100(1):203–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17660506

Pena-Philippides JC, Razani-Boroujerdi S, Singh SP, Langley RJ, Mishra NC, Henderson RF, et al. Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. Toxicol Sci [Internet]. 2007 May [cited 2013 Oct 14];97(1):181–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17301067

Pottenger LH, Malley LA, Bogdanffy MS, Donner EM, Upton PB, Li Y, et al. Evaluation of effects from repeated inhalation exposure of F344 rats to high concentrations of propylene. Toxicol Sci [Internet]. 2007 Jun [cited 2013 Oct 14];97(2):336–47. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17341482

Powley MW, Walker VE, Li Y, Upton PB, Swenberg JA. The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity. Chem Biol Interact [Internet]. 2007 Mar 20 [cited 2013 Oct 14]; 166(1-3):182–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17349618

Rowan WH, Campen MJ, Wichers LB, Watkinson WP. Heart rate variability in rodents: uses and caveats in toxicological studies. Cardiovasc Toxicol [Internet]. 2007 Jan [cited 2013 Oct 14];7(1):28–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17646680

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Inflammation

Kamisoglu K, Haimovich B, Calvano SE, Coyle SM, Corbett SA, Langley RJ, et al. Human metabolic response to systemic inflammation: assessment of the concordance between experimental endotoxemia and clinical cases of sepsis/SIRS. Crit Care [Internet]. 2015 Jan [cited 2015 May 4];19(1):71. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4383069&tool=pmcentrez&rendertype=abstract

Chand HS, Harris JF, Mebratu YA, Chen Y, Wright PS, Randell SH, et al. Intracellular insulin-like growth factor-1 induces Bcl-2 expression in airway epithelial cells. J Immunol [Internet]. 2012 May 1 [cited 2013 Sep 17];188(9):4581–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3359962&tool=pmcentrez&rendertype=abstract

Chand HS, Woldegiorgis Z, Schwalm K, McDonald JD, Tesfaigzi Y. Acute inflammation induces insulin-like growth factor-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells. Am J Respir Cell Mol Biol [Internet]. 2012 Dec [cited 2013 Sep 17];47(6):784–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22878411

Mishra NC, Sopori ML. Immunotoxicity. In: Gupta R, editor. Veterinary Toxicology. San Diego, CA: Elsevier B.V.; 2012. p. 364–80.

Chand HS, Schuyler MR, Joste N, Hensler C, Tesfaigzi Y, Masten B, et al. Anti-IgE therapy results in decreased myeloid dendritic cells in asthmatic airways. J Allergy Clin Immunol [Internet]. 2010 May [cited 2013 Sep 27];125(5):1157–8.e5. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2866812&tool=pmcentrez&rendertype=abstract

Mehra D, Sternberg DI, Jia Y, Canfield S, Lemaitre V, Nkyimbeng T, et al. Altered lymphocyte trafficking and diminished airway reactivity in transgenic mice expressing human MMP-9 in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol [Internet]. 2010 Mar [cited 2013 Sep 30];298(2):L189–96. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2822563&tool=pmcentrez&rendertype=abstract

Sood A, Qualls C, Seagrave JC, Stidley CA, Archibeque T, Berwick M, et al. Effect of specific allergen inhalation on serum adiponectin in human asthma. Chest [Internet]. 2009 Feb [cited 2013 Oct 7];135(2):287–94. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3623933&tool=pmcentrez&rendertype=abstract

 

Infectious Disease

Farkas K, Plutzer J, Moltchanova E, Török A, Varró MJ, Domokos K, et al. Serological responses to Cryptosporidium antigens in inhabitants of Hungary using conventionally filtered surface water and riverbank filtered drinking water. Epidemiol Infect [Internet]. 2015 Jan 20 [cited 2015 Feb 9];1–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25603318

Jones SL, Madhusudhan KT, Agans K, Dearen K, Knight J, Brasel T, et al. Performance Evaluation of Two Universal Transport Media Designed for Preservation and Transport of Chalmydiae, Mycoplasma and Ureaplasma. J Med Microbiol [Internet]. 2015 Feb 24 [cited 2015 Mar 9];64(Pt 4):382–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25713205

Kajon AE, Hang J, Hawksworth A, Metzgar D, Hage E, Hansen CJ, et al. Molecular epidemiology of adenovirus type 21 respiratory strains isolated from US military trainees (1996-2014). J Infect Dis [Internet]. 2015 Mar 6 [cited 2015 Apr 13]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25748322

Zang N, Li S, Li W, Xie X, Ren L, Long X, et al. Resveratrol suppresses persistent airway inflammation and hyperresponsivess might partially via nerve growth factor in respiratory syncytial virus-infected mice. Int Immunopharmacol [Internet]. 2015 Jun 1 [cited 2015 Jun 7]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26044349

Blanco JCG, Core SB, Pletneva LM, March TH, Boukhvalova MS, Kajon AE. PROPHYLACTIC ANTIBODY TREATMENT AND INTRAMUSCULAR IMMUNIZATION REDUCE INFECTIOUS HUMAN RHINOVIRUS 16 LOAD IN THE LOWER RESPIRATORY TRACT OF CHALLENGED COTTON RATS. Trials Vaccinol [Internet]. 2014 Jan [cited 2014 Nov 4];3:52–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25328560

Blanco JC, Boukhvalova MS, Perez DR, Vogel SN, Kajon A. Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus). J Antivir Antiretrovir [Internet]. 2014 Mar 3 [cited 2015 Feb 9];6:40–2. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4307615&tool=pmcentrez&rendertype=abstract

Chu P, Cunningham AL, Yu J-J, Nguyen JQ, Barker JR, Lyons CR, et al. Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates. PLoS Pathog [Internet]. 2014 Oct [cited 2014 Oct 31];10(10):e1004439. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4207810&tool=pmcentrez&rendertype=abstract

Clay CC, Reader JR, Gerriets JE, Wang TT, Harrod KS, Miller LA. Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection. J Virol [Internet]. 2014 Jul [cited 2015 Jan 24];88(13):7412–25. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4054429&tool=pmcentrez&rendertype=abstract

Davis LE, Koster FT, Cawthon A. Neurologic aspects of influenza viruses. Handb Clin Neurol [Internet]. 2014 Jan [cited 2014 Aug 6];123:619–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25015508

Hutt JA, Lovchik J, Drysdale M, Sherwood RL, Brasel TL, Lipscomb MF, et al. Lethal Factor, but Not Edema Factor, Is Required to Cause Fatal Anthrax in Cynomolgus Macaques after Pulmonary Spore Challenge. Am J Pathol [Internet]. 2014 Oct 5 [cited 2014 Nov 5]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25285720

Jie Z, Sun W, Wang S, Koster FT, Li B, Harrod KS. The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model. Braz J Infect Dis [Internet]. 2014 Jan [cited 2014 Dec 8];18(4):406–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24780366

Kajon AE, Lamson D, Shudt M, Oikonomopoulou Z, Fisher BT, Klieger S, et al. Identification of a novel intertypic recombinant species D human adenovirus in a pediatric stem cell transplant recipient. J Clin Virol [Internet]. 2014 Sep 28 [cited 2014 Dec 8];61(4):496–502. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25449172

Barrett EG, Royer CM, Nicodem J, Gaskins G, Gianinni G, Wilder JA, et al. Viral exacerbation is associated with steroid insensitive neutrophilia, ILC2s, and AHR in HDM-sensitized BALB/c mice. American Thoracic Society Annual Conference. San Diego, CA; 2014.

Clay CC, Donart N, Fomukong N, Knight JB, Overheim KA, Tipper JL, et al. Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses. Immun Ageing [Internet]. 2014 Jan [cited 2014 Apr 7];11(1):4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24642138

Mitzel DN, Jaramillo RJ, Stout-Delgado HW, Senft AP, Harrod KS. Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium. J Gen Virol [Internet]. 2014 Jan [cited 2014 Feb 20];95(Pt 1):26–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24114793

Mitzel DN, Lowry VK, Shirali AC, Liu Y, Stout-Delgado HW. Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection. J Immunol [Internet]. 2014 May 1 [cited 2014 Jun 7];192(9):4273–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24670807

Tollestrup K, Frost FJ, Kunde TR, Yates M V, Jackson S. Cryptosporidium infection, onsite wastewater systems and private wells in the arid Southwest. J Water Health [Internet]. 2014 Mar [cited 2014 Jun 10];12(1):161–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24642442

Wilder JA, Mega W, Sprague C, Hunzeker JT, Makvandi M, D’Egidio G, et al. Vaccine immunogenicity and efficacy of wild type and mutant (PA SNKE167-DFF-315-E308D) recombinant Bacillus Anthracis (rPA) molecules in a rabbit model of inhalational anthrax. ASM Biodefense and Emerging Diseases Research Meeting. Washington, DC; 2014.

Ahn SH, Tsalik EL, Cyr DD, Zhang Y, van Velkinburgh JC, Langley RJ, et al. Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. PLoS One [Internet]. 2013 Jan [cited 2014 Feb 5];8(1):e48979. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3541361&tool=pmcentrez&rendertype=abstract

Armien B, Pascale JM, Muñoz C, Mariñas J, Núñez H, Herrera M, et al. Hantavirus Fever without Pulmonary Syndrome in Panama. Am J Trop Med Hyg [Internet]. 2013 Sep [cited 2013 Sep 17];89(3):489–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23836565

Gundavarapu S, Mishra NC, Singh SP, Langley RJ, Saeed AI, Feghali-Bostwick CA, et al. HIV gp120 Induces Mucus Formation in Human Bronchial Epithelial Cells through CXCR4/α7-Nicotinic Acetylcholine Receptors. PLoS One [Internet]. 2013 Jan [cited 2013 Nov 21];8(10):e77160. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3796539&tool=pmcentrez&rendertype=abstract

Jaggi P, Kajon AE, Mejias A, Ramilo O, Leber A. Human adenovirus infection in Kawasaki disease: a confounding bystander? Clin Infect Dis [Internet]. 2013 Jan [cited 2014 Jan 30];56(1):58–64. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3732045&tool=pmcentrez&rendertype=abstract

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Metzgar D, Osuna MA, Kajon AE, Hawksworth AW, Irvine M, Russell KL. Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. J Infect Dis [Internet]. 2007 Nov 15 [cited 2013 Oct 14];196(10):1465–73. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18008225

Obot Akata CJ, Blair LF, Barr EB, Storch S, Vigil G, Campen MJ. Development of a head-out plethysmograph system for non-human primates in an Animal Biosafety Level 3 facility. J Pharmacol Toxicol Methods [Internet]. 2007 [cited 2013 Oct 14];55(1):96–102. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16737832

Peng W, Zhuang J, Harrod KS, Xu F. Respiratory syncytial virus infection in anesthetized weanling rather than adult rats prolongs the apneic responses to right atrial injection of capsaicin. J Appl Physiol [Internet]. 2007 Jun [cited 2013 Oct 14];102(6):2201–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17363622

Beauchemin CAA, Forrest S, Koster FT. Modeling influenza viral dynamics in tissue. In: Bersini H, Carneiro J, editors. The 5th International Conference on Artificial Immune Systems (ICARIS). Berlin: Springer-Verlag; 2006. p. 23–36.

Campen MJ, Milazzo ML, Fulhorst CF, Obot Akata CJ, Koster FT. Characterization of shock in a hamster model of hantavirus infection. Virology [Internet]. 2006 [cited 2013 Oct 21];356(1-2):45–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16950493

Heninger S, Drysdale M, Lovchik J, Hutt JA, Lipscomb MF, Koehler TM, et al. Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax. Infect Immun [Internet]. 2006 Nov [cited 2013 Oct 21];74(11):6067–74. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1695493&tool=pmcentrez&rendertype=abstract

Koster FT, Levy H. Hantavirus cardiopulmonary syndrome - a new twist to an established pathogen. In: Fong I, Alibek K, editors. New and Evolving Infections of the 21st Century. New York, NY: Kluwers Academic/Plenum; 2006. p. 151–70.

Lu W, Hisatsune A, Koga T, Kato K, Kuwahara I, Lillehoj EP, et al. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol [Internet]. 2006 Apr 1 [cited 2013 Oct 21];176(7):3890–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16547220

Russell KL, Broderick MP, Franklin SE, Blyn LB, Freed NE, Moradi E, et al. Transmission dynamics and prospective environmental sampling of adenovirus in a military recruit setting. J Infect Dis [Internet]. 2006 Oct 1 [cited 2013 Oct 24];194(7):877–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16960774

Wang S-Z, Harrod KS. The immunobiology of respiratory syncytial virus infection. Clin Appl Immunol Rev. 2006;6(1):37–62.

Warrender C, Forrest S, Koster FT. Modeling intercellular interactions in early Mycobacterium infection. Bull Math Biol [Internet]. 2006 Nov [cited 2013 Oct 16];68(8):2233–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17086496

Xiao R, Yang S, Koster FT, Ye C, Stidley CA, Hjelle B. Sin Nombre viral RNA load in patients with hantavirus cardiopulmonary syndrome. J Infect Dis [Internet]. 2006 Nov 15 [cited 2013 Oct 24];194(10):1403–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17054070

Bohn AA, Harrod KS, Teske S, Lawrence BP. Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content. Chem Biol Interact [Internet]. 2005 Aug 15 [cited 2013 Oct 25];155(3):181–90. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16040023

Lung Injury

Awji EG, Seagrave JC, Tesfaigzi Y. Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice. Toxicol Sci [Internet]. 2015 Jun 1 [cited 2015 Jun 8]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26032511

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, et al. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med [Internet]. 2015 Feb 14 [cited 2015 Mar 9];7(1):12. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4355149&tool=pmcentrez&rendertype=abstract

Laucho-Contreras ME, Taylor KL, Mahadeva R, Boukedes SS, Owen CA. Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice. J Vis Exp [Internet]. 2015 Jan [cited 2015 Feb 9];(95). Available from: http://www.ncbi.nlm.nih.gov/pubmed/25651034

Lin R-L, Lin Y-J, Xu F, Lee L-Y. Hemorrhagic hypotension-induced hypersensitivity of vagal pulmonary C-fibers to chemical stimulation and lung inflation in anesthetized rats. Am J Physiol Regul Integr Comp Physiol [Internet]. 2015 Jan 14 [cited 2015 Feb 9];308(7):R605–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25589016

Patel AS, Song JW, Chu SG, Mizumura K, Osorio JC, Shi Y, et al. Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary Fibrosis. PLoS One [Internet]. 2015 Jan [cited 2015 Apr 13];10(3):e0121246. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4364993&tool=pmcentrez&rendertype=abstract

T Filipczak P, P Senft A, Seagrave J, Weber W, J Kuehl P, E Fredenburgh L, et al. NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury. Toxicol Sci [Internet]. 2015 Apr 13 [cited 2015 May 4]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25870319

Roychaudhuri R, Hergrueter AH, Polverino F, Laucho-Contreras ME, Gupta K, Borregaard N, et al. ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils: Regulation of Expression and Contributions to Extracellular Matrix Protein Degradation during Acute Lung Injury. J Immunol [Internet]. 2014 Jul 25 [cited 2014 Aug 6]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25063875

Cicchitto G, Musella V, Acitorio M, Capuano N, Fiorenzano G, Owen CA, et al. Idiopathic pulmonary fibrosis and coronary artery disease. Multidiscip Respir Med [Internet]. 2014 Jan [cited 2014 Jul 5];9(1):31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4074111&tool=pmcentrez&rendertype=abstract

Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, et al. Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis. PLoS One [Internet]. 2014 Jan [cited 2014 Jun 10];9(5):e97485. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4020836&tool=pmcentrez&rendertype=abstract

Filipczak P, Senft AP, Seagrave JC, Weber WM, Kuehl PJ, Fredenburgh LE, et al. Treatment of Lung Injury from Phosgene Chemical Inhalation with NOS-2 Inhibition. Society of Toxicology. Phoenix, AZ; 2014.

Gundavarapu S, Zhuang J, Barrett EG, Xu F, Russell RG, Sopori ML. A critical role of acute bronchoconstriction in the mortality associated with high-dose sarin inhalation: effects of epinephrine and oxygen therapies. Toxicol Appl Pharmacol [Internet]. 2014 Jan 15 [cited 2014 Apr 7];274(2):200–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24269878

Osorio JC, Shi Y, Patino-Jaramillo N, Tang X, Villalba JA, Doyle-Eisele ML, et al. Syndecan-2 Loss of Function Augments Murine Experimental Lung Fibrosis. American Thoracic Society Annual Conference. San Diego, CA; 2014.

Patino-Jaramillo N, Osorio JC, Wilder JA, Tang X, Mihalek A, Villalba JA, et al. Syndecan-2 Abrogates Radiation-Induced Fibrosis by inhibiting Rho-A/ROCK signaling. American Thoracic Society Annual Conference. San Diego, CA; 2014.

Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, et al. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med [Internet]. 2013 Jul 24 [cited 2013 Sep 19];5(195):195ra95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23884467

Clay CC, Donart N, Fomukong N, Knight JB, Lei W, Price L, et al. Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge. J Virol [Internet]. 2012 Apr [cited 2013 Sep 17];86(8):4234–44. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3318632&tool=pmcentrez&rendertype=abstract

Constantin M, Choi AJS, Cloonan SM, Ryter SW. Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease. Int J Hypertens [Internet]. 2012 Jan [cited 2013 Sep 17];2012:859235. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3296197&tool=pmcentrez&rendertype=abstract

He W, Wang Q, Xu J, Xu X, Padilla MT, Ren G, et al. Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation. Autophagy [Internet]. 2012 Dec [cited 2013 Sep 24];8(12):1811–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23051914

Mishra NC, Rir-sima-ah J, Grotendorst GR, Langley RJ, Singh SP, Gundavarapu S, et al. Inhalation of sulfur mustard causes long-term T cell-dependent inflammation: possible role of Th17 cells in chronic lung pathology. Int Immunopharmacol [Internet]. 2012 May [cited 2013 Sep 24];13(1):101–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3340497&tool=pmcentrez&rendertype=abstract

Benson JM, Gomez AP, Wolf ML, Tibbetts BM, March TH. The acute toxicity, tissue distribution, and histopathology of inhaled ricin in Sprague Dawley rats and BALB/c mice. Inhal Toxicol [Internet]. 2011 Apr [cited 2013 Sep 24];23(5):247–56. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21473711

Benson JM, Seagrave JC, Weber WM, Santistevan CD, Grotendorst GR, Schultz GS, et al. Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury. Wound Repair Regen [Internet]. 2011 [cited 2013 Sep 24];19(3):348–57. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3650627&tool=pmcentrez&rendertype=abstract

Benson JM, Tibbetts BM, Weber WM, Grotendorst GR. Uptake, tissue distribution, and excretion of 14C-sulfur mustard vapor following inhalation in F344 rats and cutaneous exposure in hairless guinea pigs. J Toxicol Environ Health A [Internet]. 2011 Jan [cited 2013 Sep 24];74(13):875–85. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21598172

Benson JM, Wolf ML, Kajon AE, Tibbetts BM, Bourdelais AJ, Baden DG, et al. Brevetoxin inhalation alters the pulmonary response to influenza A in the male F344 rat. J Toxicol Environ Health A [Internet]. 2011 Jan [cited 2013 Sep 24];74(5):313–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3444170&tool=pmcentrez&rendertype=abstract

Weber WM, Kracko DA, Lehman MR, Cox CE, Cheng YS, Grotendorst GR, et al. Dermal and ocular exposure systems for the development of models of sulfur mustard-induced injury. Toxicol Mech Methods [Internet]. 2011 Sep [cited 2013 Sep 27];21(7):547–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21473735

Mishra NC, Rir-sima-ah J, March TH, Weber WM, Benson JM, Jaramillo RJ, et al. Sulfur mustard induces immune sensitization in hairless guinea pigs. Int Immunopharmacol [Internet]. 2010 Mar [cited 2013 Sep 30];10(2):193–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2815140&tool=pmcentrez&rendertype=abstract

Seagrave JC, Weber WM, Grotendorst GR. Sulfur mustard vapor effects on differentiated human lung cells. Inhal Toxicol [Internet]. 2010 Sep [cited 2013 Sep 30];22(11):896–902. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3214633&tool=pmcentrez&rendertype=abstract

Weber WM, Kracko DA, Lehman MR, Irvin CM, Blair LF, White RK, et al. Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicol Mech Methods [Internet]. 2010 Jan [cited 2013 Sep 30];20(1):14–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3154732&tool=pmcentrez&rendertype=abstract

LeClaire RD, Millard C. Ricin and related toxins: review and perspective. In: Romano JJ, Lukey B, Salem H, editors. Chemical warfare agents: chemistry, pharmacology, toxicology and therapeutics. Boca Raton, FL: CRC Press, Taylor & Francis Group; 2008. p. 423–68.

Xu J, Xu F, Barrett EG. Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice. Am J Physiol Lung Cell Mol Physiol [Internet]. 2008 Jul [cited 2013 Oct 14];295(1):L162–70. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2494786&tool=pmcentrez&rendertype=abstract

Zhuang J, Xu F, Campen MJ, Zhang C, Pena-Philippides JC, Sopori ML. Inhalation of the nerve gas sarin impairs ventilatory responses to hypercapnia and hypoxia in rats. Toxicol Appl Pharmacol [Internet]. 2008 Nov 1 [cited 2013 Oct 14];232(3):440–7. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3466117&tool=pmcentrez&rendertype=abstract

Gilfeather F, Hamine V, Helman P, Hutt JA, Loring T, Lyons CR, et al. Learning and modeling biosignatures from tissue images. Comput Biol Med [Internet]. 2007 Nov [cited 2013 Oct 14];37(11):1539–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17433283

Koga T, Kuwahara I, Lillehoj EP, Lu W, Miyata T, Isohama Y, et al. TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication. Am J Physiol Lung Cell Mol Physiol [Internet]. 2007 Sep [cited 2013 Sep 25];293(3):L693–701. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17575006

Pena-Philippides JC, Razani-Boroujerdi S, Singh SP, Langley RJ, Mishra NC, Henderson RF, et al. Long- and short-term changes in the neuroimmune-endocrine parameters following inhalation exposures of F344 rats to low-dose sarin. Toxicol Sci [Internet]. 2007 May [cited 2013 Oct 14];97(1):181–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17301067

Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, et al. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol [Internet]. 2006 May [cited 2013 Oct 18];34(5):523–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16618787

Kuwahara I, Lillehoj EP, Lu W, Singh IS, Isohama Y, Miyata T, et al. Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line. Am J Physiol Lung Cell Mol Physiol [Internet]. 2006 Sep [cited 2013 Oct 21];291(3):L407–16. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16632517

Wang R, Xu F, Zhuang J, Zhang C. Carotid sinus nerve is involved in cardiorespiratory responses to intracarotid injection of capsaicin in the rat. J Appl Physiol [Internet]. 2006 Jan [cited 2013 Oct 24];100(1):60–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16150846

Weber WM, Kracko DA, Lehman MR, Irvin CM, Blair LF, White RK, et al. Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury. Toxicol Mech Methods [Internet]. 2010 Jan [cited 2013 Sep 30];20(1):14–24. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3154732&tool=pmcentrez&rendertype=abstract

Mind Research Network Publications

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Radiation

Heintz P, Heintz B, Sandoval D, Weber W, Melo D, Guilmette R. SU-E-T-481: In Vivo and Post Mortem Animal Irradiation: Measured Vs. Calculated Doses. Med Phys [Internet]. 2015 Jun [cited 2015 Jul 10];42(6):3445. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26128145

Hoover MD, Myers DS, Cash LJ, Guilmette RA, Kreyling WG, Oberdörster G, et al. Application of an informatics-based decision-making framework and process to the assessment of radiation safety in nanotechnology. Health Phys [Internet]. 2015 Feb [cited 2015 Jan 5];108(2):179–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25551501

Doyle-Eisele ML, Weber WM, Melo DR, Guilmette RA. Whole-body distribution of americium in rats for different pathways of intake. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1068–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24844378

Fornalski KW, Cohen M, Cuttler JM, Dobrzyński L, Doss M, Esposito VJ, et al. French nuclear power plants and childhood leukemia. Dose Response [Internet]. 2014 Dec [cited 2015 Jan 5];12(4):518–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25552953

Melo DR, Weber WM, Doyle-Eisele ML, Guilmette RA. Comparison of plutonium systemic distribution in rats and dogs with published data in humans. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1025–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24669776

Scott BR. Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy. J Cell Commun Signal [Internet]. 2014 Oct 17 [cited 2014 Nov 5]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25324149

Scott BR, Potter C. Stochastic Threshold Exponential (TE) Model for Hematopoietic Tissue Reconstitution Deficit after Radiation Damage. Dose Response [Internet]. 2014 Jul [cited 2014 Oct 6];12(3):415–28. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4146333&tool=pmcentrez&rendertype=abstract

Weber WM, Doyle-Eisele ML, Melo DR, Guilmette RA. Whole-body distribution of plutonium in rats for different routes of exposure. Int J Radiat Biol [Internet]. 2014 Nov [cited 2015 Jan 5];90(11):1011–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24552148

Melo DR, Lipsztein JL, Leggett RW, Bertelli L, Guilmette RA. Efficacy of Prussian blue on 137Cs decorporation therapy. Health Phys [Internet]. 2014 May [cited 2014 Apr 7];106(5):592–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24670908

Socol Y, Dobrzyński L, Doss M, Feinendegen LE, Janiak MK, Miller ML, et al. Commentary: ethical issues of current health-protection policies on low-dose ionizing radiation. Dose Response [Internet]. 2014 May [cited 2014 Jul 7];12(2):342–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4036401&tool=pmcentrez&rendertype=abstract

Scott BR, Bruce V, Gott KM, Wilder JA, March TH. Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice. Dose Response. 2013;10(4):527–40.

Scott BR, Gott KM, Potter C, Wilder JA. A Comparison of In Vivo Cellular Responses to Cs-137 Gamma Rays And 320-kV X Rays. Dose Response [Internet]. 2013 Jan [cited 2013 Dec 9];11:444–59. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3834739&tool=pmcentrez&rendertype=abstract

Scott BR, Hutt JA, Lin Y, Padilla MT, Gott KM, Potter C. Biological microdosimetry based on radiation cytotoxicity data. Radiat Prot Dosimetry [Internet]. 2013 Jan [cited 2013 Sep 23];153(4):417–24. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22869817

Bruce V, Belinsky SA, Gott KM, Liu Y, March TH, Scott BR, et al. Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice. Dose Response. 2012;10(4):516–26.

Griffiths NM, Wilk JC, Abram MC, Renault D, Chau Q, Helfer N, et al. Internal contamination by actinides after wounding: a robust rodent model for assessment of local and distant actinide retention. Health Phys [Internet]. 2012 Aug [cited 2013 Sep 19];103(2):187–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22951478

Miller G, Bertelli L, Klare K, Weber WM, Doyle-Eisele ML, Guilmette RA. Software for empirical building of biokinetic models for normal and decorporation-affected data. Health Phys [Internet]. 2012 Oct [cited 2014 Feb 17];103(4):484–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22929474

Scott BR, Dobrzyński L. Special issue introduction. Dose Response [Internet]. 2012 Jan [cited 2013 Sep 30];10(4):462–6. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2889506&tool=pmcentrez&rendertype=abstract

Shankar GN, Weber WM, Doyle-Eisele ML, Guilmette RA. Efficacy of a novel orally administered formulation of DTPA tablets for decorporating an intravenously injected radionuclide: a comparison with intravenously administered licensed DTPA. Drug Dev Res. 2012;73(5):290–8.

Weber WM, Doyle-Eisele ML, Seilkop SK, Guilmette RA. Biokinetics of systemically distributed 60Co in the rat: an experimental model useful in evaluating medical countermeasures for internal contamination. Health Phys [Internet]. 2012 Oct [cited 2013 Sep 24];103(4):474–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22929473

Romanov SA, Lyovkina Y V, Guilmette RA. Microdistribution of plutonium in lung. In: MF K, Romanov SA, editors. Radioactive Sources and Radiation Exposure Effects on the Mayak PA Workers and Population Living in the Area of Nuclear Facility Influence Part III. Chelyabinsk: Chelyabinsk Publishing House; 2011. p. 68–90.

Scott BR. Residential radon appears to prevent lung cancer. Dose Response [Internet]. 2011 Jan [cited 2013 Sep 24];9(4):444–64. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3315166&tool=pmcentrez&rendertype=abstract

Scott BR. Low-dose-radiation activated natural protection and LNT. Health Phys [Internet]. 2011 Mar [cited 2013 Sep 24];100(3):337–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21595088

Scott BR. Modeling DNA double-strand break repair kinetics as an epiregulated cell-community-wide (epicellcom) response to radiation stress. Dose Response [Internet]. 2011 Jan [cited 2013 Sep 24];9(4):579–601. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3315173&tool=pmcentrez&rendertype=abstract

Scott BR. Assessing potential radiological harm to fukushima recovery workers. Dose Response [Internet]. 2011 Jan [cited 2013 Sep 24];9(3):301–12. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3186926&tool=pmcentrez&rendertype=abstract

Smith GB, Grof Y, Navarrette A, Guilmette RA. Exploring biological effects of low level radiation from the other side of background. Health Phys [Internet]. 2011 Mar [cited 2013 Sep 24];100(3):263–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21595063

Boice JD, Cohen SS, Mumma MT, Ellis ED, Eckerman KF, Leggett RW, et al. Updated mortality analysis of radiation workers at Rocketdyne (Atomics International), 1948-2008. Radiat Res [Internet]. 2011 Aug [cited 2013 Sep 24];176(2):244–58. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21381866

Bertelli L, Waters TL, Miller G, Gadd MS, Eaton MC, Guilmette RA. Three plutonium chelation cases at Los Alamos National Laboratory. Health Phys [Internet]. 2010 Oct [cited 2013 Sep 27];99(4):532–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20838095

Guilmette RA. Editorial, 10th International Conference on Health Effects of Incorporated Radionuclides. Health Phys [Internet]. 2010 Sep [cited 2013 Sep 27];99(3):285. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20699687

Hahn FF, Scott BR, Lundgren DL. Comparative stochastic effects of alpha, beta or x-irradiation of the lung of rats. Health Phys [Internet]. 2010 Sep [cited 2013 Sep 27];99(3):363–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20699698

Cheng YS, Kenoyer JL, Guilmette RA, Parkhurst MA. Physicochemical characterization of Capstone depleted uranium aerosols II: particle size distributions as a function of time. Health Phys [Internet]. 2009 Mar [cited 2013 Sep 30];96(3):266–75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204485

Guilmette RA, Cheng YS. Physicochemical characterization of Capstone depleted uranium aerosols IV: in vitro solubility analysis. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 1];96(3):292–305. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204487

Guilmette RA, Miller G, Parkhurst MA. Capstone depleted uranium aerosol biokinetics, concentrations, and doses. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 1];96(3):328–42. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204489

Hahn FF, Roszell LE, Daxon EG, Guilmette RA, Parkhurst MA. Radiological risk assessment of Capstone depleted uranium aerosols. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 1];96(3):352–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204491

Holmes TD, Guilmette RA, Cheng YS, Parkhurst MA, Hoover MD. Aerosol sampling system for collection of Capstone depleted uranium particles in a high-energy environment. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 1];96(3):221–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204482

Krupka KM, Parkhurst MA, Gold K, Arey BW, Jenson ED, Guilmette RA. Physicochemical characterization of Capstone depleted uranium aerosols III: morphologic and chemical oxide analyses. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 1];96(3):276–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204486

Miller G, Cheng YS, Traub RJ, Little TT, Guilmette RA. Methods used to calculate doses resulting from inhalation of Capstone depleted uranium aerosols. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 7];96(3):306–27. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204488

Parkhurst MA, Cheng YS, Kenoyer JL, Traub RJ. Physicochemical characterization of Capstone depleted uranium aerosols I: uranium concentration in aerosols as a function of time and particle size. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 7];96(3):251–65. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204484

Parkhurst MA, Guilmette RA. Conclusions of the Capstone depleted uranium aerosol characterization and risk assessment study. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 7];96(3):393–409. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204494

Parkhurst MA, Guilmette RA. Overview of the Capstone depleted uranium study of aerosols from impact with armored vehicles: test setup and aerosol generation, characterization, and application in assessing dose and risk. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 7];96(3):207–20. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204481

Roszell LE, Hahn FF, Lee RB, Parkhurst MA. Assessing the renal toxicity of Capstone depleted uranium oxides and other uranium compounds. Health Phys [Internet]. 2009 Mar [cited 2013 Oct 7];96(3):343–51. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19204490

Scott BR. Calculating pulmonary-mode-lethality risk avoidance associated with radionuclide decorporation countermeasures related to a radiological terrorism incident. Dose Response [Internet]. 2009 Jan [cited 2013 Sep 30];8(1):83–96. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2836159&tool=pmcentrez&rendertype=abstract

Scott BR. Calculating hematopoietic-mode-lethality risk avoidance associated with radionuclide decorporation countermeasures related to a radiological terrorism incident. Dose Response [Internet]. 2009 Jan [cited 2013 Oct 7];7(4):332–57. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2790316&tool=pmcentrez&rendertype=abstract

Belyaeva ZD, Osovets S V, Scott BR, Zhuntova G V, Grigoryeva ES. Modeling of respiratory system dysfunction among nuclear workers: a preliminary study. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 11];6(4):319–32. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2592993&tool=pmcentrez&rendertype=abstract

Guilmette RA. Introduction of the 31st Lauriston Taylor Lecturer in radiation protection and measurements, Patricia W. Durbin. Health Phys [Internet]. 2008 Nov [cited 2013 Oct 11];95(5):462–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18849678

Muggenburg BA, Guilmette RA, Hahn FF, Diel JH, Mauderly JL, Seilkop SK, et al. Radiotoxicity of inhaled (239)PuO(2) in dogs. Radiat Res [Internet]. 2008 Dec [cited 2013 Oct 14];170(6):736–57. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19138039

Rithidech KN, Scott BR. Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(3):252–71. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2564764&tool=pmcentrez&rendertype=abstract

Scott BR. Low-dose radiation risk extrapolation fallacy associated with the linear-no-threshold model. Hum Exp Toxicol [Internet]. 2008 Feb [cited 2013 Oct 14];27(2):163–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18480143

Scott BR. Radiation-adaptive-response-based cancer risk modeling, Report NIRS-M-211. Proceedings of the NIRS International Symposium on the Effects of Low Dose Radiation. 2008. p. 44–51.

Scott BR. It’s time for a new low-dose-radiation risk assessment paradigm--one that acknowledges hormesis. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(4):333–51. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2592992&tool=pmcentrez&rendertype=abstract

Scott BR. Low-dose-radiation stimulated natural chemical and biological protection against lung cancer. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(3):299–318. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2564762&tool=pmcentrez&rendertype=abstract

Scott BR, Sanders CL, Mitchel RE, Boreham DR. CT Scans May Reduce Rather Than Increase the Risk of Cancer. J Am Physicians Surg. 2008;13(1):8–11.

Day TK, Zeng G, Hooker AM, Bhat M, Scott BR, Turner DR, et al. Adaptive response for chromosomal inversions in pKZ1 mouse prostate induced by low doses of X radiation delivered after a high dose. Radiat Res [Internet]. 2007 Jun [cited 2013 Oct 14];167(6):682–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17523846

Harrison J, Leggett RW, Lloyd D, Phipps A, Scott BR. Polonium-210 as a poison. J Radiol Prot [Internet]. 2007 Mar [cited 2013 Oct 14];27(1):17–40. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17341802

Lyon CM, Klinge DM, Liechty KC, Gentry FD, March TH, Kang T, et al. Radiation-induced lung adenocarcinoma is associated with increased frequency of genes inactivated by promoter hypermethylation. Radiat Res [Internet]. 2007 Oct [cited 2013 Oct 14];168(4):409–14. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17903034

Scott BR. Natural background radiation-induced apoptosis and the maintenance of mammalian life on earth. In: Vinter L, editor. New Cell Apoptosis Research. Hauppage, NY: Nova Science Publishers; 2007. p. 1–35.

Scott BR. Health risk evaluations for ingestion exposure of humans to polonium-210. Dose Response [Internet]. 2007 Jan [cited 2013 Oct 14];5(2):94–122. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2477690&tool=pmcentrez&rendertype=abstract

Scott BR. Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy. Dose Response [Internet]. 2007 Jan [cited 2013 Oct 14];5(2):131–49. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2477691&tool=pmcentrez&rendertype=abstract

Scott BR. Radiation hormesis and the control of genomic instability. In: Gloscow E, editor. New Research on Genomic Instability. Hauppage, NY: Nova Science Publishers; 2007. p. 139–80.

Scott BR, Di Palma J. Sparsely ionizing diagnostic and natural background radiations are likely preventing cancer and other genomic-instability-associated diseases. Dose Response [Internet]. 2007 Jan [cited 2013 Oct 15];5(3):230–55. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2477699&tool=pmcentrez&rendertype=abstract

Scott BR, Haque M, DiPalma J. Biological basis for radiation hormesis in mammalian cellular communities. Int J Low Radiat. 2007;4(1):1–16.

Day TK, Zeng G, Hooker AM, Bhat M, Scott BR, Turner DR, et al. Extremely low priming doses of X radiation induce an adaptive response for chromosomal inversions in pKZ1 mouse prostate. Radiat Res [Internet]. 2006 Nov [cited 2013 Oct 21];166(5):757–66. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17067212

Irshad H, Su W-C, Cheng YS, Medici F. Testing of high-volume sampler inlets for the sampling of atmospheric radionuclides. Health Phys [Internet]. 2006 Sep [cited 2013 Oct 21];91(3):188–99. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16891894

Scott BR. Re: Risk of thyroid cancer after exposure to (131)I in childhood. J Natl Cancer Inst [Internet]. 2006 Apr 19 [cited 2013 Oct 24];98(8):561; author reply 561. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16622126

Tokarskaya ZB, Zhuntova G V, Scott BR, Khokhryakov VF, Belyaeva ZD, Vasilenko EK, et al. Influence of alpha and gamma radiations and non-radiation risk factors on the incidence of malignant liver tumors among Mayak PA workers. Health Phys [Internet]. 2006 Oct [cited 2013 Oct 24];91(4):296–310. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16966873

Cheng YS, Holmes TD, George TG, Marlow WH. Size measurement of plutonium particles from internal sputtering into air. Nucl Instruments Methods Phys Res Sect B Beam Interact with Mater Atoms. 2005;234(3):219–25.

Tobacco Smoke

Awji EG, Seagrave JC, Tesfaigzi Y. Correlation of Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema in C3H and C57Bl/6 Mice. Toxicol Sci [Internet]. 2015 Jun 1 [cited 2015 Jun 8]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26032511

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, et al. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med [Internet]. 2015 Feb 14 [cited 2015 Mar 9];7(1):12.

Zhuang J, Zhao L, Zang N, Xu F. Prenatal Nicotinic Exposure Augments Cardiorespiratory Responses to Activation of Bronchopulmonary C-fibers. Am J Physiol Lung Cell Mol Physiol [Internet]. 2015 Mar 6 [cited 2015 Apr 13];ajplung.00241.2014. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25747962

Moon H-G, Kim S-H, Gao J, Quan T, Qin Z, Osorio JC, et al. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am J Physiol Lung Cell Mol Physiol [Internet]. 2014 Aug 15 [cited 2014 Oct 23];307(4):L326–37. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24973403

Laucho-Contreras ME, Taylor KL, Mahadeva R, Boukedes SS, Owen CA. Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice. J Vis Exp [Internet]. 2015 Jan [cited 2015 Feb 9];(95). Available from: http://www.ncbi.nlm.nih.gov/pubmed/25651034

Polverino F, Doyle-Eisele ML, McDonald JD, Wilder JA, Royer CM, Laucho-Contreras ME, et al. A Novel Nonhuman Primate Model of Cigarette Smoke-Induced Airway Disease. Am J Pathol [Internet]. 2014 Dec 23 [cited 2015 Jan 5]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25542772

Tessema M, Yingling CM, Liu Y, Tellez CS, Van Neste L, Baylin SS, et al. Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers. Carcinogenesis [Internet]. 2014 Jun [cited 2014 Sep 9];35(6):1248–57. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24398667

Holmes TD, McDonald JD, Kuehl PJ, Kracko DA. Characterization of the Blu e-cigarette to define the composition of inhaled material. Society of Toxicology. Phoenix, AZ; 2014.

Nyunoya T, Mebratu YA, Contreras AU, Delgado M, Chand HS, Tesfaigzi Y. Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol [Internet]. 2014 Mar [cited 2014 Apr 29];50(3):471–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24111585

Xu X, Padilla MT, Li B, Wells A, Kato K, Tellez CS, et al. MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer. Cancer Res [Internet]. 2014 Jan 15 [cited 2014 Mar 24];74(2):460–70. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24282280

Zhuang J, Zhao L, Xu F. Maternal nicotinic exposure produces a depressed hypoxic ventilatory response and subsequent death in postnatal rats. Physiol Rep [Internet]. 2014 May 1 [cited 2014 Jun 10];2(5). Available from: http://www.ncbi.nlm.nih.gov/pubmed/24872357

Jang J-H, Bruse SE, Liu Y, Duffy V, Zhang C, Oyamada N, et al. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radic Biol Med [Internet]. 2013 Dec 4 [cited 2014 Jan 6];68C:80–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24316006

Petersen H V, Sood A, Meek P, Shen X, Cheng Y, Belinsky SA, et al. Rapid Lung Function Decline in Smokers is a Risk Factor for COPD and is Attenuated by ACE Inhibitor Use. Chest [Internet]. 2013 Sep 5 [cited 2014 Feb 27]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/24008986

Singh SP, Gundavarapu S, Smith KR, Chand HS, Saeed AI, Mishra NC, et al. Gestational exposure of mice to secondhand cigarette smoke causes bronchopulmonary dysplasia blocked by the nicotinic receptor antagonist mecamylamine. Environ Health Perspect [Internet]. 2013 Aug [cited 2013 Sep 19];121(8):957–64. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3734504&tool=pmcentrez&rendertype=abstract

Chen W, Xu X, Bai L, Padilla MT, Gott KM, Leng S, et al. Low-dose gamma-irradiation inhibits IL-6 secretion from human lung fibroblasts that promotes bronchial epithelial cell transformation by cigarette-smoke carcinogen. Carcinogenesis [Internet]. 2012 Jul [cited 2014 Feb 19];33(7):1368–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22556270

Leng S, Stidley CA, Liu Y, Edlund CK, Willink RP, Han Y, et al. Genetic determinants for promoter hypermethylation in the lungs of smokers: a candidate gene-based study. Cancer Res [Internet]. 2012 Feb 1 [cited 2013 Sep 24];72(3):707–15. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3271143&tool=pmcentrez&rendertype=abstract

Sharma P, Kolawole AO, Core SB, Kajon AE, Excoffon KJDA. Sidestream smoke exposure increases the susceptibility of airway epithelia to adenoviral infection. PLoS One [Internet]. 2012 Jan [cited 2014 Feb 18];7(11):e49930. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3499494&tool=pmcentrez&rendertype=abstract

Sood A, Petersen H V, Blanchette CM, Meek P, Picchi MA, Belinsky SA, et al. Methylated Genes in Sputum Among Older Smokers With Asthma. Chest [Internet]. 2012 Aug [cited 2013 Sep 24];142(2):425–31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3425338&tool=pmcentrez&rendertype=abstract

Bruse SE, Sood A, Petersen H V, Liu Y, Leng S, Celedón JC, et al. New Mexican Hispanic smokers have lower odds of chronic obstructive pulmonary disease and less decline in lung function than non-Hispanic whites. Am J Respir Crit Care Med [Internet]. 2011 Dec 1 [cited 2013 Sep 24];184(11):1254–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3262041&tool=pmcentrez&rendertype=abstract

Leng S, Bernauer AM, Hong C, Do KC, Yingling CM, Flores KG, et al. The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res [Internet]. 2011 Apr 1 [cited 2013 Sep 24];17(7):2014–23. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3070839&tool=pmcentrez&rendertype=abstract

Mebratu YA, Schwalm K, Smith KR, Schuyler MR, Tesfaigzi Y. Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia. Am J Respir Crit Care Med [Internet]. 2011 Jun 1 [cited 2013 Sep 24];183(11):1531–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3137142&tool=pmcentrez&rendertype=abstract

Nyunoya T, March TH, Tesfaigzi Y, Seagrave JC. Antioxidant diet protects against emphysema, but increases mortality in cigarette smoke-exposed mice. COPD [Internet]. 2011 Oct [cited 2013 Sep 24];8(5):362–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3323122&tool=pmcentrez&rendertype=abstract

Razani-Boroujerdi S, Langley RJ, Singh SP, Pena-Philippides JC, Rir-sima-ah J, Gundavarapu S, et al. The role of IL-1β in nicotine-induced immunosuppression and neuroimmune communication. J Neuroimmune Pharmacol [Internet]. 2011 Dec [cited 2013 Sep 24];6(4):585–96. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21671006

Singh SP, Gundavarapu S, Pena-Philippides JC, Rir-Sima-ah J, Mishra NC, Wilder JA, et al. Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation. J Immunol [Internet]. 2011 Nov 1 [cited 2013 Sep 24];187(9):4542–52. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3197944&tool=pmcentrez&rendertype=abstract

Xu J, Xu F, Lin Y. Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α secretion from macrophages via substance P-mediated nuclear factor-κB activation. Am J Respir Cell Mol Biol [Internet]. 2011 Mar [cited 2013 Sep 27];44(3):302–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3095931&tool=pmcentrez&rendertype=abstract

Mishra NC, Rir-sima-ah J, Boyd RT, Singh SP, Gundavarapu S, Langley RJ, et al. Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors. J Immunol [Internet]. 2010 Jul 1 [cited 2013 Sep 30];185(1):588–96. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2954495&tool=pmcentrez&rendertype=abstract

Olivera DS, Knall C, Boggs SE, Seagrave JC. Cytoskeletal modulation and tyrosine phosphorylation of tight junction proteins are associated with mainstream cigarette smoke-induced permeability of airway epithelium. Exp Toxicol Pathol [Internet]. 2010 Mar [cited 2013 Sep 30];62(2):133–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19376691

Pickett G, Seagrave JC, Boggs SE, Polzin G, Richter P, Tesfaigzi Y. Effects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies. Toxicol Sci [Internet]. 2010 Mar [cited 2013 Sep 30];114(1):79–89. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20015843

Xu J, Xu F. Role of neurogenic substance P in overexpression of alveolar macrophages’ neurokinin 1 receptor in mice exposed to cigarette smoke. Exp Lung Res [Internet]. 2010 May [cited 2013 Sep 30];36(4):243–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20426532

Adenuga D, Yao H, March TH, Seagrave JC, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol [Internet]. 2009 Apr [cited 2013 Sep 30];40(4):464–73. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2660563&tool=pmcentrez&rendertype=abstract

Singh SP, Mishra NC, Rir-Sima-Ah J, Campen MJ, Kurup VP, Razani-Boroujerdi S, et al. Maternal exposure to secondhand cigarette smoke primes the lung for induction of phosphodiesterase-4D5 isozyme and exacerbated Th2 responses: rolipram attenuates the airway hyperreactivity and muscarinic receptor expression but not lung inflammation and a. J Immunol [Internet]. 2009 Aug 1 [cited 2013 Oct 7];183(3):2115–21. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3191864&tool=pmcentrez&rendertype=abstract

Leng S, Bernauer AM, Stidley CA, Picchi MA, Sheng X, Frasco MA, et al. Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers. Cancer Epidemiol Biomarkers Prev [Internet]. 2008 Aug [cited 2013 Oct 14];17(8):2062–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18708399

Leng S, Stidley CA, Willink RP, Bernauer AM, Do KC, Picchi MA, et al. Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. Cancer Res [Internet]. 2008 Apr 15 [cited 2013 Oct 14];68(8):3049–56. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2483467&tool=pmcentrez&rendertype=abstract

Mishra NC, Rir-Sima-Ah J, Langley RJ, Singh SP, Pena-Philippides JC, Koga T, et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. J Immunol [Internet]. 2008 Jun 1 [cited 2013 Oct 14];180(11):7655–63. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2614131&tool=pmcentrez&rendertype=abstract

Sanders CL, Scott BR. Smoking and hormesis as confounding factors in radiation pulmonary carcinogenesis. Dose Response [Internet]. 2008 Jan [cited 2013 Oct 14];6(1):53–79. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2477723&tool=pmcentrez&rendertype=abstract

Sood A, Stidley CA, Picchi MA, Celedón JC, Gilliland FD, Crowell RE, et al. Difference in airflow obstruction between Hispanic and non-Hispanic White female smokers. COPD [Internet]. 2008 Oct [cited 2013 Oct 14];5(5):274–81. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3616889&tool=pmcentrez&rendertype=abstract

Hahn FF, Gigliotti AP, Hutt JA, March TH, Mauderly JL. A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice. Int J Toxicol [Internet]. 2007 [cited 2013 Oct 14];26(4):307–13. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17661221

Liu H, Zhou Y, Boggs SE, Belinsky SA, Liu J. Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B. Oncogene [Internet]. 2007 Aug 30 [cited 2013 Oct 14];26(40):5900–10. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17369845

Olivera DS, Boggs SE, Beenhouwer C, Aden JK, Knall C. Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro. Inhal Toxicol [Internet]. 2007 Jan [cited 2013 Oct 14];19(1):13–22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17127639

Razani-Boroujerdi S, Boyd RT, Dávila-García MI, Nandi JS, Mishra NC, Singh SP, et al. T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response. J Immunol [Internet]. 2007 Sep 1 [cited 2013 Oct 14];179(5):2889–98. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17709503

Razani-Boroujerdi S, Sopori ML. Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. Am J Respir Cell Mol Biol [Internet]. 2007 Jan [cited 2013 Oct 14];36(1):13–9. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1899301&tool=pmcentrez&rendertype=abstract

Xu F, Zhuang J, Wang R, Seagrave JC, March TH. Blunted ventilatory response to hypoxia/hypercapnia in mice with cigarette smoke-induced emphysema. Respir Physiol Neurobiol [Internet]. 2007 Aug 15 [cited 2013 Oct 18];158(1):5–13. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2703296&tool=pmcentrez&rendertype=abstract

Xu J, Xu F, Wang R, Seagrave JC, Lin Y, March TH. Cigarette smoke-induced hypercapnic emphysema in C3H mice is associated with increases of macrophage metalloelastase and substance P in the lungs. Exp Lung Res [Internet]. 2007 [cited 2013 Oct 18];33(5):197–215. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17620183

March TH, Wilder JA, Esparza DC, Cossey PY, Blair LF, Herrera LK, et al. Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice. Toxicol Sci [Internet]. 2006 Aug [cited 2013 Oct 22];92(2):545–59. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16699168

Phaybouth V, Wang S-Z, Hutt JA, McDonald JD, Harrod KS, Barrett EG. Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model. Am J Physiol Lung Cell Mol Physiol [Internet]. 2006 Feb [cited 2013 Oct 24];290(2):L222–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16126789

Singh SP, Razani-Boroujerdi S, Pena-Philippides JC, Langley RJ, Mishra NC, Sopori ML. Early postnatal exposure to cigarette smoke impairs the antigen-specific T-cell responses in the spleen. Toxicol Lett [Internet]. 2006 Dec 15 [cited 2013 Oct 24];167(3):231–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17113252

Other

Mezzles MJ, Dick EJ, Owston MA, Bauer C. Osteosarcoma in Baboons (Papio spp). Comp Med [Internet]. 2015 Jan [cited 2015 May 4];65(2):144–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25926401

Tsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, et al. Renal systems biology of patients with systemic inflammatory response syndrome. Kidney Int [Internet]. 2015 May 20 [cited 2015 May 22]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/25993322

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Rogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, et al. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One [Internet]. 2014 Jan [cited 2014 Mar 3];9(1):e87538. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3907548&tool=pmcentrez&rendertype=abstract

Liu Y, Nyunoya T, Leng S, Belinsky SA, Tesfaigzi Y, Bruse SE. Softwares and methods for estimating genetic ancestry in human populations. Hum Genomics. 2013;7:1.

Ponce F, Smith KR, Matchett CA. Response to protocol review scenario: above the regulations. Lab Anim (NY) [Internet]. 2013 Mar [cited 2013 Sep 23];42(3):82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23423294

Zhang Z, Zhuang J, Zhang C, Xu F. Isoflurane depolarizes bronchopulmonary C neurons by inhibiting transient A-type and delayed rectifier potassium channels. Respir Physiol Neurobiol [Internet]. 2013 Apr 1 [cited 2013 Nov 21];186(2):164–72. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23357616

Zhang Z, Zhuang J, Zhang C, Xu F. Isoflurane inhibits bronchopulmonary C-fiber-mediated apneic response to phenylbiguanide by depressing 5-HT3 receptor function in anesthetized rats. Neurosci Lett [Internet]. 2013 Sep 27 [cited 2014 Jun 10];552:1–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23896531

Schmiege SJ, Meek P, Bryan AD, Petersen H V. Latent variable mixture modeling: a flexible statistical approach for identifying and classifying heterogeneity. Nurs Res [Internet]. 2012 [cited 2014 Feb 20];61(3):204–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22551995

Sood A, Petersen H V, Blanchette CM, Meek P, Picchi MA, Belinsky SA, et al. Methylated Genes in Sputum Among Older Smokers With Asthma. Chest [Internet]. 2012 Aug [cited 2013 Sep 24];142(2):425–31. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3425338&tool=pmcentrez&rendertype=abstract

Glasser SW, Senft AP. Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis. Curr Pharm Biotechnol [Internet]. 2011 Sep [cited 2013 Sep 24];12(9):1447–54. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21401520

Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, et al. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis [Internet]. 2010 Jan [cited 2013 Sep 30];22(1):135–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/20847439

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