Lovelace is a preeminent research and development facility for medical countermeasures (MCM, biological, chemical, radiological, explosives, combat casualty care). LBERI can work with agents requiring containment and chemical surety (meets the minimum requirements for AR50-6 Chemical Surety), select agent (CDC) as well as those requiring Nuclear Regulatory Commission (NRC)-approved facilities. We undertake regulated studies in efforts to complete FDA Animal Rule Investigational New Drugs (INDs) leading to full New Drug Application (NDA)/Biologic License Application (BLA) programs.
The Applied Science and Toxicology Division at Lovelace was established in 1963 to assist the government (Atomic Energy Commission) in characterizing the potential harmful effects of radiation and has published over 1000 manuscripts in the fields of radiation dosimetry, and health hazards. Lovelace has been performing external radiation models for over 20 years. In recent years our team has developed and validated models of acute radiation syndrome, dermal burn/radiation combinations, and systemic injury models in the gastrointestinal and cardiopulmonary systems. Our staff participate in animal model development consortia and are leading researchers in the area of radiation dosimetry, radiation drug countermeasure drug development and risk assessment. Overall, our radiation research team is unparalleled.
Select Agents and Toxins
Lovelace has registered its North and South Campus with the CDC/APHIS select agent program. These facilities can work with various bacterial and viral agents, as well as toxins, that require BSL-3 and/or ABSL-3 enhanced containment. Lovelace has current biosafety and incident response plans in place to address biosafety practices during normal operations and emergencies.
These procedures include reporting requirements for exposures and releases.
CDC has approved Lovelace for the following agents:
The LBERI Hazardous Materials Exposure Laboratory (HMEL) is used for the conduct of chemical warfare agent (CWA)/toxic industrial chemical (TIC) exposures. The laboratory is in compliance with the chemical weapons convention as well as local and state laws that permit the synthesis and storage of chemical agents that permit the synthesis and storage of chemical agents listed under the chemical weapons convention. The laboratory has been conducting research with chemical agents for the department of defense starting in 1995.
This laboratory is located in a secure wing that is dedicated to the conduct of studies to highly toxic chemical agents such as:
We apply many novel tools to our models, including pulmonary and neurophysiology (ie EEG) and imaging with CT/MRI.
In summary, Lovelace offers the medical countermeasure community: