LRRI’s Bioanalytical Chemistry Department supports preclinical and clinical development. The Bioanalytical Chemistry Department provides a state-of-the-art infrastructure with experience in chromatography, mass spectrometry, and immunoaffinity assays. LRRI has the experience and tools required to develop or transfer methods on small molecules, proteins, or peptides, all of which can be conducted in strict compliance with Good Laboratory Practices.

 

LRRI’s Bioanalytical Chemistry Department has conducted a range of bioanalytical assays to support PK/TK and metabolism studies. Analysis can be conducted to assay concentrations of parent molecules or compounds in a full range of matrixes including blood, plasma, serum, urine, and tissue. As required, drug metabolism can also be characterized in a similar range of matrixes.

Key Capabilities

• Validated suite of instruments
• Parent molecule analysis
• Metabolism characterization
• Development/transfer of bioanalytical assays
• Validation of methods
• QA/QC interface to ensure compliance with GLPs

Instrumentation

The Bioanalytical Chemistry Department provides a range of state-of-the-art, validated instrumentation including:

• Mass Spectrometer Systems
  • API 5000 – Agilent 1200 LC w/ DAD
  • API 4000 – Agilent 1200 LC
  • API 365 EP10+ Upgrade – Shimadzu LC
• HPLC Systems
• Agilent 1100 – DAD, VWD, RID, FLD detectors
• Agilent 6980 and 5980 – MS and FID detectors
• Perkin Elmer Lambda 35
• BioTek Elisa System
• GC Systems
• Spectrophotometers
• Elisa Plate Reader