CPSP capabilities include telemetry, plethysmography, ultrasound, several in vitro assays including vascular or bronchial ring or isolated lung assays, as well as molecular biology tools to investigate cardiovascular and respiratory disease models, and better understand the mechanism(s) of the disease. CPSP also investigates the cardiovascular and pulmonary physiological effects and safety of new compounds developed by our pharmaceutical clients.
CPSP’s telemetry capability includes four ITS telemetry (GLP), three DSI/Ponemah, and one DSI/EMKA (GLP) acquisition systems. CPSP is aligned with investigators in Infectious diseases, as telemetry has proven to be an especially powerful tool in providing accurate information regarding the effects of infectious agents and the efficacy of applied therapies. CPSP is also aligned with investigators in COPD, asthma, toxicology, and chemical exposure.
Ultrasound/Echocardiography: Rodent, Ferret, Rabbit, Dog/NHP
Small Animal Telemetry (DSI): Mouse, Rat, Ferret, Rabbit
Large Animal telemetry (DSI): Dog and NHP
Large Animal Telemetry (ITS): NHP standard telemetry parameters: blood pressure and heart rate, ECG assessment (QRS duration and PR, RR, QT/QTc and arrhythmia assessment)
In Vitro: Vascular ring function
Cellular: Western blots, RT-PCR, Northern/Southern gels, In situ zymography, cryosectioning for IHC staining, double immunofluorescence, specialty stains
Traditional Restrained/Anesthetized Plethysmography in rodent (FlexiVent) and non-rodent species: respiratory mechanics, forced maneuvers, quasistatic maneuvers, lung diffusion capacity, airway challenges
Unrestrained Whole Body Plethysmography in rodents or guinea pigs (EMKA Technologies; GLP): respiratory rate, volume, penH, inspiratory and expiratory times, apnea
In Vitro: Bronchial ring function and isolated lung function
Chemistry (Tier II: arterial blood gas analysis): iSTAT and Siemens Rapidpoint 405 analyzer for laboratory testing of blood gases, electrolytes, metabolites, total hemoglobin, and hemoglobin derivatives in arterial, venous, and capillary whole blood samples.
Central Nervous System
Rodent Functional Observational Battery (FOB)
Chemical Withdrawal Assessment
ACCESS LRRI PUBLICATIONS ON THIS TOPIC IN PUBMED
Safety Pharmacology Society http://www.safetypharmacology.org/
Society of Toxicology http://www.toxicology.org/
ICHS7A guidelines Safety Pharmacology
ICHS7B guidelines Safety Pharmacology
January 2010 Guidance Assessment of Abuse Potential of Drugs
ICHS6 guidelines Biotechnology-Derived Pharmaceuticals
ICHS4A guidelines Chronic Toxicity Testing
ICHS9 guidance Nonclinical Evaluation for Anticancer Pharmaceuticals